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Case Reports
. 2020 Feb 22:11:2042098620905976.
doi: 10.1177/2042098620905976. eCollection 2020.

Secukinumab-induced Raynaud's phenomenon: first report in the literature

Senol Kobak  1
Affiliations
Case Reports

Secukinumab-induced Raynaud's phenomenon: first report in the literature

Senol Kobak. Ther Adv Drug Saf. .

Abstract

Secukinumab is an IL-17A antagonist that has proven efficacy in the treatment of patients with ankylosing spondylitis (AS) and psoriatic arthritis. Side effects of the drug include infections, skin rashes, and allergic reactions. Raynaud's phenomenon (RP), a vasospastic syndrome and an important feature of different connective tissue diseases, is not an expected finding in AS patients. This article reports the development of secukinumab-related RP in a 35-year-old female patient with AS. Treatment with secukinumab was continued and RP was treated with low-dose aspirin and a calcium-channel blocker.

Keywords: Raynaud’s phenomenon; ankylosing spondylitis; secukinumab.

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Conflict of interest statement

Conflict of interest statement: The author declares that there is no conflict of interest.

Figures

Figure 1.
Figure 1.
Raynaud’s phenomenon (three color changes) of the hand after secukinumab injection.
See this image and copyright information in PMC

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