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Case Reports
. 2020 Jan 14;8(2):374-378.
doi: 10.1002/ccr3.2654. eCollection 2020 Feb.

A hidden cause of infertility in hypothyroid patients

Magdy Mohamed Allam  1 , Hanaa Tarek El-Zawawy  2 , Sherine Samir Barakat  3 , Soha Magdy Ahmed  1 , Rasha Noureldin M Saleh  4   5
Affiliations
Case Reports

A hidden cause of infertility in hypothyroid patients

Magdy Mohamed Allam et al. Clin Case Rep. .

Abstract

Methylene tetrahydrofolate reductase (MTHFR) gene mutations could be the cause of infertility in hypothyroid patients. Hence, it is worthy to screen for MTHFR gene mutations in infertile hypothyroid females and their partners if infertility persists after optimizing thyroid function.

Keywords: 5‐methyl tetrahydrofolate; Hashimoto's thyroiditis; hypothyroidism; infertility; methylene tetrahydrofolate reductase; miscarriage; pregnancy loss.

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Conflict of interest statement

The author state that there are no conflicts of interest.

Figures

Figure 1
Figure 1
Schematic figure showing the process by which folate/folic acid is used for methylation & antioxidation. MTHFR, methylenetetrahydrofolate reductase; SAH, S‐adenosylhomocysteine; SAM, S‐adenosylmethionine; THF, tetrahydrofolate
See this image and copyright information in PMC

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