Life Expectancy of Insured People With and Without Hepatitis C Virus Infection, 2007-2017

doi:10.1093/ofid/ofaa044

. 2020 Feb 5;7(2):ofaa044.

doi: 10.1093/ofid/ofaa044. eCollection 2020 Feb.

Life Expectancy of Insured People With and Without Hepatitis C Virus Infection, 2007-2017

Julia L Marcus^{1

2}, Leo B Hurley¹, Scott Chamberland³, Jamila H Champsi⁴, Daniel G Korn⁵, Jennifer B Lai⁶, Jennifer O Lam¹, Charles P Quesenberry Jr¹, Joanna Ready⁷, Varun Saxena⁴, Suk I Seo^{8

9}, David J Witt⁶, Michael J Silverberg¹

Affiliations

¹ Kaiser Permanente Division of Research, Oakland, California, USA.
² Harvard Medical School and Harvard Pilgrim Health Care Institute, Boston, Massachusetts, USA.
³ Kaiser Permanente Northern California Regional Pharmacy, Oakland, California, USA.
⁴ Kaiser Permanente South San Francisco Medical Center, South San Francisco, California, USA.
⁵ Kaiser Permanente Oakland Medical Center, Oakland, California, USA.
⁶ Kaiser Permanente San Rafael Medical Center, San Rafael, California, USA.
⁷ Kaiser Permanente Santa Clara Medical Center, Santa Clara, California, USA.
⁸ Kaiser Permanente Antioch Medical Center, Antioch, California.
⁹ Kaiser Permanente Walnut Creek Medical Center, Walnut Creek, California, USA.

PMID: 32128339
PMCID: PMC7043807
DOI: 10.1093/ofid/ofaa044

Life Expectancy of Insured People With and Without Hepatitis C Virus Infection, 2007-2017

Julia L Marcus et al. Open Forum Infect Dis. 2020.

. 2020 Feb 5;7(2):ofaa044.

doi: 10.1093/ofid/ofaa044. eCollection 2020 Feb.

Authors

Affiliations

¹ Kaiser Permanente Division of Research, Oakland, California, USA.
² Harvard Medical School and Harvard Pilgrim Health Care Institute, Boston, Massachusetts, USA.
³ Kaiser Permanente Northern California Regional Pharmacy, Oakland, California, USA.
⁴ Kaiser Permanente South San Francisco Medical Center, South San Francisco, California, USA.
⁵ Kaiser Permanente Oakland Medical Center, Oakland, California, USA.
⁶ Kaiser Permanente San Rafael Medical Center, San Rafael, California, USA.
⁷ Kaiser Permanente Santa Clara Medical Center, Santa Clara, California, USA.
⁸ Kaiser Permanente Antioch Medical Center, Antioch, California.
⁹ Kaiser Permanente Walnut Creek Medical Center, Walnut Creek, California, USA.

PMID: 32128339
PMCID: PMC7043807
DOI: 10.1093/ofid/ofaa044

Abstract

Among 25 291 and 4 921 830 people with and without hepatitis C, life expectancy at age 20 increased 1.8 years and 0.3 years from the interferon to interferon-free era, respectively. Increases were highest for racial and/or ethnic minority groups with hepatitis C.

Keywords: direct-acting antiviral agents; hepatitis C virus (HCV); mortality; survival; treatment.

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Figures

**Figure 1.**
Life expectancy at age 20 for people with and without hepatitis C virus (HCV) by treatment era and for people with HCV by sex and race/ethnicity.

See this image and copyright information in PMC

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References

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[1] Ly KN, Hughes EM, Jiles RB, Holmberg SD. Rising mortality associated with hepatitis C virus in the United States, 2003–2013. Clin Infect Dis 2016; 62:1287–8. - PMC - PubMed

[2] Ly KN, Hughes EM, Jiles RB, Holmberg SD. Rising mortality associated with hepatitis C virus in the United States, 2003–2013. Clin Infect Dis 2016; 62:1287–8. - PMC - PubMed

[3] Jakobsen JC, Nielsen EE, Feinberg J, et al. . Direct-acting antivirals for chronic hepatitis C. Cochrane Database Syst Rev 2017; 9:CD012143. - PMC - PubMed

[4] Jakobsen JC, Nielsen EE, Feinberg J, et al. . Direct-acting antivirals for chronic hepatitis C. Cochrane Database Syst Rev 2017; 9:CD012143. - PMC - PubMed

[5] Powderly WG, Naggie S, Kim AY, et al. . IDSA/AASLD response to cochrane review on direct-acting antivirals for hepatitis C. Clin Infect Dis 2017; 65:1773–5. - PubMed

[6] Powderly WG, Naggie S, Kim AY, et al. . IDSA/AASLD response to cochrane review on direct-acting antivirals for hepatitis C. Clin Infect Dis 2017; 65:1773–5. - PubMed

[7] Backus LI, Belperio PS, Shahoumian TA, Mole LA. Direct-acting antiviral sustained virologic response: impact on mortality in patients without advanced liver disease. Hepatology 2018; 68:827–38. - PubMed

[8] Backus LI, Belperio PS, Shahoumian TA, Mole LA. Direct-acting antiviral sustained virologic response: impact on mortality in patients without advanced liver disease. Hepatology 2018; 68:827–38. - PubMed

[9] McGlynn EA, Adams JL, Kramer J, et al. . Assessing the safety of direct-acting antiviral agents for hepatitis C. JAMA Netw Open 2019; 2:e194765. - PMC - PubMed

[10] McGlynn EA, Adams JL, Kramer J, et al. . Assessing the safety of direct-acting antiviral agents for hepatitis C. JAMA Netw Open 2019; 2:e194765. - PMC - PubMed

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Life Expectancy of Insured People With and Without Hepatitis C Virus Infection, 2007-2017

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Life Expectancy of Insured People With and Without Hepatitis C Virus Infection, 2007-2017

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