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. 2020 Apr;9(7):e1901697.
doi: 10.1002/adhm.201901697. Epub 2020 Mar 3.

A Needle-Type Microrobot for Targeted Drug Delivery by Affixing to a Microtissue

Seungmin Lee  1 , Jin-Young Kim  1 , Junyoung Kim  1 , Ali Kafash Hoshiar  2 , Jongeon Park  1 , Sunkey Lee  1 , Jonghyun Kim  3 , Salvador Pané  4 , Bradley J Nelson  4 , Hongsoo Choi  1
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A Needle-Type Microrobot for Targeted Drug Delivery by Affixing to a Microtissue

Seungmin Lee et al. Adv Healthc Mater. 2020 Apr.

Abstract

A needle-type microrobot (MR) for targeted drug delivery is developed to stably deliver drugs to a target microtissue (MT) for a given period time without the need for an external force after affixing. The MRs are fabricatedby 3D laser lithography and nickel (Ni)/titanium oxide (TiO2 ) layers are coated by physical vapor deposition. The translational velocity of the MR is 714 µm s-1 at 20 mT and affixed to the target MT under the control of a rotating magnetic field. The manipulability of the MR is shown by using both manual and automatic controls. Finally, drug release from the paclitaxel-loaded MR is characterized to determine the efficiency of targeted drug delivery. This study demonstrates the utility of the proposed needle-type MR for targeted drug delivery to MT with various flow rates in vitro physiological fluidic environments.

Keywords: drug delivery; fixation; magnetic manipulation; microrobots; targeted drug delivery.

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