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. 2020 Mar 3;22(3):e16770.
doi: 10.2196/16770.

Deep Digital Phenotyping and Digital Twins for Precision Health: Time to Dig Deeper

Guy Fagherazzi  1
Affiliations

Deep Digital Phenotyping and Digital Twins for Precision Health: Time to Dig Deeper

Guy Fagherazzi. J Med Internet Res. .

Abstract

This viewpoint describes the urgent need for more large-scale, deep digital phenotyping to advance toward precision health. It describes why and how to combine real-world digital data with clinical data and omics features to identify someone's digital twin, and how to finally enter the era of patient-centered care and modify the way we view disease management and prevention.

Keywords: big data; data lake; deep digital phenotyping; digital cohort; digital epidemiology; digital health; digital orthodoxy; digital phenotyping; digitosome; omics; personalized medicine; precision health; precision medicine; precision prevention.

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Conflict of interest statement

Conflicts of Interest: None declared.

Figures

Figure 1
Figure 1
The concept of deep digital phenotyping and digital twin identification for precision health.
See this image and copyright information in PMC

References

    1. Psaty BM, Dekkers OM, Cooper RS. Comparison of 2 Treatment Models: Precision Medicine and Preventive Medicine. JAMA. 2018 Aug 28;320(8):751–752. doi: 10.1001/jama.2018.8377. - DOI - PubMed
    1. Wise HC, Solit DB. Precision Oncology: Three Small Steps Forward. Cancer Cell. 2019 Jun 10;35(6):825–826. doi: 10.1016/j.ccell.2019.05.009. - DOI - PMC - PubMed
    1. Muse ED, Topol EJ. Digital orthodoxy of human data collection. The Lancet. 2019 Aug;394(10198):556. doi: 10.1016/s0140-6736(19)31727-1. - DOI - PubMed
    1. Wynn RM, Adams KT, Kowalski RL, Shivega WG, Ratwani RM, Miller KE. The Patient in Precision Medicine: A Systematic Review Examining Evaluations of Patient-Facing Materials. J Healthc Eng. 2018;2018:9541621. doi: 10.1155/2018/9541621. doi: 10.1155/2018/9541621. - DOI - DOI - PMC - PubMed
    1. Kasztura M, Richard A, Bempong N, Loncar D, Flahault A. Cost-effectiveness of precision medicine: a scoping review. Int J Public Health. 2019 Dec;64(9):1261–1271. doi: 10.1007/s00038-019-01298-x. http://europepmc.org/abstract/MED/31650223 - DOI - PMC - PubMed

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