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Review
. 2020 Jun;55(6):579-587.
doi: 10.1007/s00535-020-01678-8. Epub 2020 Mar 4.

Objective evaluation for treat to target in Crohn's disease

Kento Takenaka  1   2 , Yoshio Kitazume  3 , Toshimitsu Fujii  4 , Kiichiro Tsuchiya  4 , Mamoru Watanabe  4   5 , Kazuo Ohtsuka  6
Affiliations
Review

Objective evaluation for treat to target in Crohn's disease

Kento Takenaka et al. J Gastroenterol. 2020 Jun.

Abstract

Background: Crohn's disease (CD) is a chronic and destructive bowel disease; continued disease activity can lead to penetrating complications. With the recent advent of effective medications, the importance of using a treat-to-target approach to guide therapy is becoming important.

Methods: In this review, we reviewed the previous evidence for evaluating CD lesions.

Results: We describe ileocolonoscopy's role in assessing disease activity, as well as recent progress in modalities, such as balloon-assisted endoscopy, capsule endoscopy, magnetic resonance enterography, computed tomography enterography, and ultrasonography. Advances in modalities have changed CD assessment, with small-bowel involvement becoming more important.

Conclusions: Proper optimization is necessary in clinical practice.

Keywords: Endoscopy; Enterography; Inflammatory bowel disease; Mucosal healing; Ultrasonography.

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Conflict of interest statement

Employment/Leadership position/ Advisory role: Mitsubishi Tanabe Pharma Corporation, Takeda Pharmaceutical Company Limited (KTs).

Figures

Fig. 1
Fig. 1
Examinations for evaluation of Crohn’s disease
See this image and copyright information in PMC

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