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Comment
. 2020 Mar 3;31(3):441-442.
doi: 10.1016/j.cmet.2020.02.005.

Appetite for Arginine: Metabolic Control of Macrophage Hunger

Daniel J Puleston  1 , Erika L Pearce  2
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Appetite for Arginine: Metabolic Control of Macrophage Hunger

Daniel J Puleston et al. Cell Metab. .
Free article

Abstract

Engulfment of dying cells by phagocytes is essential to maintain tissue function and promote injury resolution and repair. This process, termed efferocytosis, requires persistent corpse engulfment and remains a poorly understood mechanism. Here, we preview findings from Yurdagul et al. (2020) that detail how continual efferocytosis is supported by metabolites derived from the dying cell itself.

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Conflict of interest statement

Declaration of Interests E.L.P. is a Scientific Advisory Board Member of ImmunoMet Therapeutics, Inc. and a founder of Rheos Medicines.

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