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. 2020 Mar 3;28(3):274-276.
doi: 10.1016/j.str.2020.02.003.

How CBP/Shank3 Guards Rap and H-Ras

Dhrubajyoti Chowdhury  1 , Johannes W Hell  2
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How CBP/Shank3 Guards Rap and H-Ras

Dhrubajyoti Chowdhury et al. Structure. .
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Abstract

In this issue of Structure, Cai et al. (2020) describe crystal structures of the postsynaptic protein Shank3, a homolog of cortactin binding protein 1 (CBP1), in complex with small G proteins Rap1 and H-Ras. Functional studies suggest that binding of Ras and Rap to Shank3 is modulated by synaptic plasticity.

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