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Comment
. 2020 Mar 3;28(3):277-279.
doi: 10.1016/j.str.2020.02.004.

A Structural Understanding of Class B GPCR Selectivity and Activation Revealed

Brian Krumm  1 , Bryan L Roth  2
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A Structural Understanding of Class B GPCR Selectivity and Activation Revealed

Brian Krumm et al. Structure. .
Free article

Abstract

Ma et al. (2020) and Liang et al. (2020) describe the cryo-EM structures of three class B G protein-coupled receptors (GPCRs) in complex with native peptides and Gs. Their work establishes the structural basis of peptide specificity and a conserved mechanism of receptor activation and G protein coupling for class B GPCRs.

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