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Multicenter Study
. 2020 Jun;30(3):226-230.
doi: 10.1111/tme.12671. Epub 2020 Mar 4.

Parvovirus B19 infection in sickle cell disease: An analysis from the Centers for Disease Control haemoglobinopathy blood surveillance project

Suvankar Majumdar  1   2 , Christopher J Bean  3 , Christine De Staercke  3 , James Bost  1 , Robert Nickel  1 , Thomas Coates  4 , Andrew Campbell  1   5 , Alexis Thompson  6
Affiliations
Multicenter Study

Parvovirus B19 infection in sickle cell disease: An analysis from the Centers for Disease Control haemoglobinopathy blood surveillance project

Suvankar Majumdar et al. Transfus Med. 2020 Jun.

Abstract

Objective: In the multicentre Haemoglobinopathy Blood Surveillance Project, to evaluate the seroprevalence of parvovirus B19 and DNA viral load in sickle cell disease (SCD).

Background: Although the epidemiology of parvovirus B19 seropositivity in SCD has been well documented, there are few studies that have assessed possible persistent parvovirus DNAemia and associated risk factors including blood transfusion.

Methods: A qualitative analysis of parvovirus B19 serology using ELISA and quantitative parvovirus B19 DNA by RT-PCR was performed in patients with SCD.

Results: Of 322 patients, 113 (35%) were parvovirus IgG positive and 119 (37%) were IgM positive at enrolment. The prevalence of IgG positivity increased with age. 71/322 (22%) were parvovirus DNA positive at enrolment with a mean viral load of 15 227 ± 55 227 SD. (range 72-329 238 IU/mL). Patients who were positive for parvovirus B19 DNA received a significantly higher red blood cell transfusion volume in the prior year compared to patients who were negative (mean RBC volume = 8310 mL vs 5435 mL, respectively; P = .0073). Seventy-seven patients had follow-up testing approximately 1 year after enrolment and 11/28 (39%) patients had persistently positive IgM.

Conclusion: Further studies are needed to better understand the natural history of parvovirus B19 infection in SCD especially in relation to RBC transfusion as a risk factor, as well as disease outcome and severity.

Keywords: hemoglobinopathy; parvovirus B19; sickle.

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Conflict of interest statement

CONFLICT OF INTEREST

The findings and conclusions in this report are those of the authors and do not necessarily represent the official position of the Centers for Disease Control and Prevention.

Comment in

References

    1. Hankins JS, Penkert RR, Lavoie P, Tang L, Sun Y, Hurwitz JL. Parvovirus B19 infection in children with sickle cell disease in the hydroxyurea era. Exp Biol Med (Maywood) 2016;241(7):749–754. - PMC - PubMed
    1. Smith-Whitley K, Zhao H, Hodinka RL, et al. Epidemiology of human parvovirus B19 in children with sickle cell disease. Blood. 2004;103(2): 422–427. - PubMed
    1. Zimmerman SA, Davis JS, Schultz WH, Ware RE. Subclinical parvovirus B19 infection in children with sickle cell anemia. J Pediatr Hematol Oncol. 2003;25(5):387–389. - PubMed
    1. Makhlouf MM, Elwakil SG, Ibrahim NS. Molecular and serological assessment of parvovirus B-19 infection in Egyptian children with sickle cell disease. J Microbiol Immunol Infect. 2017;50(5):565–569. 10.1016/j.jmii.2015.10.016. - DOI - PubMed
    1. Slavov SN, Kashima S, Pinto AC, Covas DT. Human parvovirus B19: general considerations and impact on patients with sickle-cell disease and thalassemia and on blood transfusions. FEMS Immunol Med Microbiol. 2011;62(3):247–262. - PubMed

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