Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Clinical Trial
. 2020 Mar 2;12(3):675.
doi: 10.3390/nu12030675.

The Course Of IGF-1 Levels and Nutrient Intake in Extremely and Very Preterm Infants During Hospitalisation

Dana F J Yumani  1 , Alexandra K Calor  1 , Mirjam M van Weissenbruch  1
Affiliations
Clinical Trial

The Course Of IGF-1 Levels and Nutrient Intake in Extremely and Very Preterm Infants During Hospitalisation

Dana F J Yumani et al. Nutrients. .

Abstract

Background: Insulin-like growth factor 1 (IGF-1) plays an important role in the complex association between nutrition, growth, and maturation in extremely and very preterm infants. Nevertheless, in this population, research on associations between IGF-1 and nutrition is limited. Therefore this study aimed to evaluate the possible associations between the course of IGF-1 levels and nutrient intake between preterm birth and 36 weeks postmenstrual age (PMA).

Methods: 87 infants born between 24 and 32 weeks gestational age were followed up to 36 weeks PMA. Actual daily macronutrient intake was calculated, and growth was assessed weekly. IGF-1 was sampled from umbilical cord blood at birth and every other week thereafter.

Results: There was an inverse relationship between the amount of parenteral nutrition in the second week of life and IGF-1. Total protein, fat, and carbohydrate intake, as well as total energy intake, primarily showed a positive association with IGF-1 levels, particularly between 30 and 33 weeks PMA. Gestational age, bronchopulmonary dysplasia (BPD), and weight were significant confounders in the association between nutrient intake and IGF-1 levels.

Conclusion: Parenteral nutrition was found to be a negative predictor of IGF-1 levels, and there could potentially be a time frame in which macronutrient intake is unable to impact IGF-1 levels. Future research should aim to narrow down this time frame and to gain more insight into factors enhancing or decreasing the response of IGF-1 to nutrition, e.g., age and inflammatory state, to align nutritional interventions accordingly.

Keywords: insulin-like growth factor; nutrient intake; postnatal growth; preterm infants.

PubMed Disclaimer

Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Flow diagram of participants included in the study.
Figure 2
Figure 2
Insulin-like growth factor 1 (IGF-1) levels in extremely preterm and very preterm infants.
Figure 3
Figure 3
Weight SD score in extremely and very preterm infants.
Figure 4
Figure 4
Parenteral and enteral nutrient intake in preterm infants in the first two weeks of life.
Figure 5
Figure 5
Nutrient intake in preterm infants in the first six weeks of life.
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Larnkjaer A., Molgaard C., Michaelsen K.F. Early nutrition impact on the insulin-like growth factor axis and later health consequences. Curr. Opin. Clin. Nutr. Metab. Care. 2012;15:285–292. doi: 10.1097/MCO.0b013e328351c472. - DOI - PubMed
    1. Yumani D.F., Lafeber H.N., van Weissenbruch M.M. Dietary proteins and IGF I levels in preterm infants: Determinants of growth, body composition, and neurodevelopment. Pediatric Res. 2015;77:156–163. doi: 10.1038/pr.2014.172. - DOI - PubMed
    1. Engstrom E., Niklasson A., Wikland K.A., Ewald U., Hellstrom A. The role of maternal factors, postnatal nutrition, weight gain, and gender in regulation of serum IGF-I among preterm infants. Pediatric Res. 2005;57:605–610. doi: 10.1203/01.PDR.0000155950.67503.BC. - DOI - PubMed
    1. Hansen-Pupp I., Löfqvist C., Polberger S., Niklasson A., Fellman V., Hellström A., Ley D. Influence of insulin-like growth factor I and nutrition during phases of postnatal growth in very preterm infants. Pediatric Res. 2011;69:448–453. doi: 10.1203/PDR.0b013e3182115000. - DOI - PubMed
    1. Smith W.J., Underwood L.E., Keyes L., Clemmons D.R. Use of insulin-like growth factor I (IGF-I) and IGF-binding protein measurements to monitor feeding of premature infants. J. Clin. Endocrinol. Metab. 1997;82:3982–3988. doi: 10.1210/jc.82.12.3982. - DOI - PubMed

Substances