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. 1977 Feb;15(2):370-5.
doi: 10.1128/iai.15.2.370-375.1977.

Cell-mediated immunity in experimental Nocardia asteroides infection

T Sundararaj, S C Agarwal

Cell-mediated immunity in experimental Nocardia asteroides infection

T Sundararaj et al. Infect Immun. 1977 Feb.

Abstract

Experimental mycetoma-like lesions developed in guinea pigs after subcutaneous injection of Nocardia asteroides. Although delayed hypersensitivity appeared earlier, increased macrophage migration inhibition and microbicidal activity appeared after 7 weeks. When the lesions healed, high cell-mediated immunity was present. Cell-mediated immunity was transferred to normal recipient guinea pigs from healed donor guinea pigs by spleen cell transfer. Recipient guinea pigs showed marked protection against challenge with N. asteroides.

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