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Comment
. 2020 Mar 4;105(5):759-761.
doi: 10.1016/j.neuron.2020.02.008.

TREM2: Modulator of Lipid Metabolism in Microglia

Eyiyemisi C Damisah  1 , Anupama Rai  2 , Jaime Grutzendler  3
Affiliations
Free article
Comment

TREM2: Modulator of Lipid Metabolism in Microglia

Eyiyemisi C Damisah et al. Neuron. .
Free article

Abstract

Lipid-processing mechanisms during demyelination are poorly understood. In this issue of Neuron,Nugent et al. (2020) show by cell-specific lipidomics that Trem2 deficiency leads to cholesterol ester (CE) overload in microglia. This is mediated by misregulation of lipid metabolism genes and is rescued by modulating CE synthesis or efflux.

Keywords: ApoE; Trem2; cholesterol transport; demyelination; lipidomics; microglia; neurodegeneration.

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  • TREM2 Regulates Microglial Cholesterol Metabolism upon Chronic Phagocytic Challenge.
    Nugent AA, Lin K, van Lengerich B, Lianoglou S, Przybyla L, Davis SS, Llapashtica C, Wang J, Kim DJ, Xia D, Lucas A, Baskaran S, Haddick PCG, Lenser M, Earr TK, Shi J, Dugas JC, Andreone BJ, Logan T, Solanoy HO, Chen H, Srivastava A, Poda SB, Sanchez PE, Watts RJ, Sandmann T, Astarita G, Lewcock JW, Monroe KM, Di Paolo G. Nugent AA, et al. Neuron. 2020 Mar 4;105(5):837-854.e9. doi: 10.1016/j.neuron.2019.12.007. Epub 2020 Jan 2. Neuron. 2020. PMID: 31902528

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