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Review
. 2020 Apr 15:579:119194.
doi: 10.1016/j.ijpharm.2020.119194. Epub 2020 Mar 2.

Recent progress in continuous manufacturing of oral solid dosage forms

V Vanhoorne  1 , C Vervaet  2
Affiliations
Review

Recent progress in continuous manufacturing of oral solid dosage forms

V Vanhoorne et al. Int J Pharm. .

Abstract

Continuous drug product manufacturing is slowly being implemented in the pharmaceutical industry. Although the benefits related to the quality and cost of continuous manufacturing are widely recognized, several challenges hampered the widespread introduction of continuous manufacturing of drug products. Current review presents an overview of state-of-the art research, equipment, process analytical technology implementations and advanced control strategies. Additionally, guidelines and regulatory viewpoints on implementation of continuous manufacturing in the pharmaceutical industry are discussed.

Keywords: Advanced process control; Continuous manufacturing; Direct compression; Process analytical technology; Roller compaction; Twin-screw granulation.

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Conflict of interest statement

Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

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