Bioconjugated gold nanoparticles as an efficient colorimetric sensor for cancer diagnostics

Abstract

The chances of curing and reducing the adverse effect of cancer partly lie in early detection. Colorimetric sensor-based technique show promising results since the target is detected with high sensitivity but without the use of advanced/costly techniques through a simple visual color change. In most cases, gold nanoparticles (Au Nps) functionalized with biomolecules complementary to target analyte are used for colorimetric detection. The interaction of functionalized Au Nps with target analytes induce aggregation or dispersion where the color of the solution changes from red to blue or blue to red respectively, which can be visualized by the naked eyes. Such a facile technique has a high commercial viability and therefore, understanding its concept is essential. Here, some of the reported studies are discussed technically for better understanding about the invitro colorimetric detection of cancer.

Keywords: Biosensor; Cancer detection; Color change; Colorimetric sensor; Functionalization; Gold nanoparticles.