Altered resting-state thalamo-occipital functional connectivity is associated with cognition in isolated rapid eye movement sleep behavior disorder

Jung-Ick Byun¹, Hyun-Woo Kim², Hyejin Kang³, Kwang Su Cha², Jun-Sang Sunwoo⁴, Jung-Won Shin⁵, Jangsup Moon⁶, Soon-Tae Lee², Keun-Hwa Jung², Kon Chu², Manho Kim⁷, Won Chul Shin¹, Dong Soo Lee⁸, Carlos H Schenck⁹, Sang Kun Lee¹⁰, Ki-Young Jung¹¹

Affiliations

¹ Department of Neurology, Kyung Hee University Hospital at Gangdong, Kyung Hee University College of Medicine, Seoul, South Korea.
² Department of Neurology, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, South Korea.
³ Department of Nuclear Medicine, Seoul National University College of Medicine, Seoul, South Korea; BK21 Plus Global Translational Research on Molecular Medicine and Biopharmaceutical Sciences, Seoul, South Korea.
⁴ Department of Neurosurgery, Seoul National University Hospital, Seoul, South Korea.
⁵ Department of Neurology, CHA University, CHA Bundang Medical Center, Seongnam, South Korea.
⁶ Department of Neurology, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, South Korea; Rare Disease Center, Seoul National University Hospital, Seoul, South Korea.
⁷ Department of Neurology, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, South Korea; Dementia Research Center, Seoul National University, Seoul, South Korea.
⁸ Department of Nuclear Medicine, Seoul National University College of Medicine, Seoul, South Korea; Department of Molecular Medicine and Biopharmaceutical Science, Graduate School of Convergence Science and Technology, Seoul National University, Seoul, South Korea.
⁹ Minnesota Regional Sleep Disorders Center, Department of Psychiatry, Hennepin County Medical Center, University of Minnesota Medical School, Minneapolis, MN.
¹⁰ Department of Neurology, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, South Korea. Electronic address: sangkun2923@gmail.com.
¹¹ Department of Neurology, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, South Korea. Electronic address: jungky@snu.ac.kr.

PMID: 32135454
DOI: 10.1016/j.sleep.2020.01.010

Altered resting-state thalamo-occipital functional connectivity is associated with cognition in isolated rapid eye movement sleep behavior disorder

Jung-Ick Byun et al. Sleep Med. 2020 May.

. 2020 May:69:198-203.

doi: 10.1016/j.sleep.2020.01.010. Epub 2020 Jan 18.

Authors

Affiliations

¹ Department of Neurology, Kyung Hee University Hospital at Gangdong, Kyung Hee University College of Medicine, Seoul, South Korea.
² Department of Neurology, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, South Korea.
³ Department of Nuclear Medicine, Seoul National University College of Medicine, Seoul, South Korea; BK21 Plus Global Translational Research on Molecular Medicine and Biopharmaceutical Sciences, Seoul, South Korea.
⁴ Department of Neurosurgery, Seoul National University Hospital, Seoul, South Korea.
⁵ Department of Neurology, CHA University, CHA Bundang Medical Center, Seongnam, South Korea.
⁶ Department of Neurology, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, South Korea; Rare Disease Center, Seoul National University Hospital, Seoul, South Korea.
⁷ Department of Neurology, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, South Korea; Dementia Research Center, Seoul National University, Seoul, South Korea.
⁸ Department of Nuclear Medicine, Seoul National University College of Medicine, Seoul, South Korea; Department of Molecular Medicine and Biopharmaceutical Science, Graduate School of Convergence Science and Technology, Seoul National University, Seoul, South Korea.
⁹ Minnesota Regional Sleep Disorders Center, Department of Psychiatry, Hennepin County Medical Center, University of Minnesota Medical School, Minneapolis, MN.
¹⁰ Department of Neurology, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, South Korea. Electronic address: sangkun2923@gmail.com.
¹¹ Department of Neurology, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, South Korea. Electronic address: jungky@snu.ac.kr.

PMID: 32135454
DOI: 10.1016/j.sleep.2020.01.010

Erratum in

Corrigendum to "Altered resting-state thalamo-occipital functional connectivity is associated with cognition in isolated rapid eye movement sleep behavior disorder" [Sleep Med 69 (2020) 198-203].
Byun JI, Kim HW, Kang H, Cha KS, Sunwoo JS, Shin JW, Moon J, Lee ST, Jung KH, Chu K, Kim M, Shin WC, Lee DS, Schenck CH, Lee SK, Jung KY. Byun JI, et al. Sleep Med. 2020 Nov;75:547. doi: 10.1016/j.sleep.2020.04.023. Epub 2020 May 23. Sleep Med. 2020. PMID: 32451159 No abstract available.

Abstract

Objective: Isolated rapid eye movement sleep behavior disorder (iRBD) patients are at risk of cognitive impairments, however the underlying mechanism is still unclear. This study aimed to evaluate thalamo-cortical functional connectivity (FC) using resting-state functional magnetic resonance imaging (fMRI) and its correlation with cognitive dysfunction in patients with iRBD.

Methods: A total 37 polysomnographies (PSGs) confirmed iRBD patients and 15 age-sex matched controls underwent resting-state fMRI and comprehensive neuropsychological assessment. Thalamo-cortical FC was evaluated by using seed-to voxel analysis and was compared between the iRBD and controls. Correlation between the average value of significant clusters and cognitive function scores in iRBD were calculated.

Results: Compared to the control subjects, patients with iRBD patients showed cognitive decline in word list recognition (p = 0.016), and constructional recall (p = 0.044). The FC analysis showed increased FC between the left thalamus and occipital regions including the right cuneal cortex, left fusiform gyrus and lingual gyrus (cluster level p < 0.05, corrected for false discovery rate). The averaged thalamo-fusiform FC value positively correlated with word list recognition after adjusting for age and sex (adjusted r = 0.347, p = 0.041).

Conclusion: Thalamic resting state FC is altered in iRBD patients and is associated with the cognitive function. Enhancement of the thalamo-occipital FC may reflect a compensatory mechanism for cognitive impairment in iRBD.

Keywords: Cognitive function; Functional brain imaging; Neuroimaging; REM sleep behavior disorder.

PubMed Disclaimer

Publication types

Actions

MeSH terms

Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions

LinkOut - more resources

Full Text Sources
- ClinicalKey
- Elsevier Science
Medical
- MedlinePlus Health Information

Save citation to file

Email citation

Add to Collections

Add to My Bibliography

Your saved search

Create a file for external citation management software

Your RSS Feed

Altered resting-state thalamo-occipital functional connectivity is associated with cognition in isolated rapid eye movement sleep behavior disorder

Affiliations

Altered resting-state thalamo-occipital functional connectivity is associated with cognition in isolated rapid eye movement sleep behavior disorder

Authors

Affiliations

Erratum in

Abstract

Publication types

MeSH terms

LinkOut - more resources

Full Text Sources

Medical