Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2020 Mar 6;20(1):190.
doi: 10.1186/s12885-020-6683-0.

Incidence and time trends of sarcoma (2000-2013): results from the French network of cancer registries (FRANCIM)

Brice Amadeo  1   2   3 , Nicolas Penel  4   5 , Jean-Michel Coindre  6 , Isabelle Ray-Coquard  7   8 , Karine Ligier  9   10 , Patricia Delafosse  9   11 , Anne-Marie Bouvier  9   12   13 , Sandrine Plouvier  9   10 , Justine Gallet  14 , Aude Lacourt  14 , Gaëlle Coureau  14   15   9   16 , Alain Monnereau  14   9   17 , Simone Mathoulin-Pélissier  14   18 , Emmanuel Desandes  9   19   20
Affiliations

Incidence and time trends of sarcoma (2000-2013): results from the French network of cancer registries (FRANCIM)

Brice Amadeo et al. BMC Cancer. .

Abstract

Background: The exhaustive collection of new sarcoma cases and their second histologic review offer a unique opportunity to study their incidence and time trends in France according to the major subtypes.

Methods: Data were collected from population-based cancer registries covering 22% of the French population. Crude and world age-standardized incidence rates (ASR) were estimated according to anatomic, histological and genetic groups, age and sex over the 2010-2013 period.

Results: Time trends in incidence were calculated by the annual percent change over the 2000-2013 period. During the most recent period (2010-2013), 3942 patients with sarcoma were included. The ASR of soft-tissue and bone sarcomas, and gastro-intestinal stromal tumors (GIST) were 2.1, 1.0 and 0.6, respectively. For the four most frequent histological subtypes (unclassified, leiomyosarcoma, GIST and liposarcoma), the ASR ranged from 0.4 to 0.7. ASRs were 1.9 for complex genomic and 1.3 for recurrent translocation sarcomas. The time-trend analysis showed a significant increase of sarcoma incidence rate between 2000 and 2005, which stabilized thereafter. Incidence rates increased for four histological subtypes (GIST, chondrosarcoma, myxofibrosarcoma, solitary fibrous tumors) and decreased for three (leiomyosarcomas, Kaposi sarcoma and fibrosarcoma).

Conclusion: To our knowledge, this study is the first to investigate sarcoma incidence based on a systematic pathological review of these cancers and on the updated sarcoma classifications. Due to the paucity of literature on sarcomas, future studies using data from population-based cancer registries should consider a standardized inclusion criterion presented in our study to better describe and compare data between countries.

Keywords: Cancer registry; France; Incidence; Sarcoma; Trends in incidence.

PubMed Disclaimer

Conflict of interest statement

The authors declare that they have no competing interests.

Figures

Fig. 1
Fig. 1
Age-specific incidence rates of sarcomas per 100,000 person-years according to topographic groups. FRANCIM network data 2010–2013 (19 registries)
See this image and copyright information in PMC

References

    1. Fletcher CDM, Bridge JA, Hogendoorn PCW, Mertens F. WHO classification of Tumours of soft tissue and bone. 4. Lyon: IARC Press; 2013.
    1. Burningham Z, Hashibe M, Spector L, Schiffman JD. The epidemiology of sarcoma. Clin Sarcoma Res. 2012;2:14. doi: 10.1186/2045-3329-2-14. - DOI - PMC - PubMed
    1. Lurkin A, Ducimetiere F, Vince DR, et al. Epidemiological evaluation of concordance between initial diagnosis and central pathology review in a comprehensive and prospective series of sarcoma patients in the Rhone-Alpes region. BMC Cancer. 2010;10:150. doi: 10.1186/1471-2407-10-150. - DOI - PMC - PubMed
    1. Antonescu CR. The role of genetic testing in soft tissue sarcoma. Histopathology. 2006;48:13–21. doi: 10.1111/j.1365-2559.2005.02285.x. - DOI - PubMed
    1. Honoré C, Méeus P, Stoeckle E, Bonvalot S. Soft tissue sarcoma in France in 2015: epidemiology, classification and organization of clinical care. J Visc Surg. 2015;152:223–230. doi: 10.1016/j.jviscsurg.2015.05.001. - DOI - PubMed

MeSH terms