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Case Reports
. 2020 Mar 6;20(1):110.
doi: 10.1186/s12887-020-2005-6.

Ménétrier's disease in childhood: a case report from China

Jiewei Zhang  1 , Yizhong Wang  1 , Haifeng Liu  1 , Yongmei Xiao  2 , Ting Zhang  1
Affiliations
Case Reports

Ménétrier's disease in childhood: a case report from China

Jiewei Zhang et al. BMC Pediatr. .

Abstract

Background: Ménétrier's disease (MD) is a protein-losing gastropathy characterized by gastric hypertrophy, foveolar hyperplasia and hypoalbuminemia. MD is uncommon in childhood with nonspecific clinical symptoms, and the exact cause of pediatric MD is still unclear.

Case presentation: Here, we reported a 4 year and 10-month boy presenting with MD from China. The patient was suffered with vomiting, abdominal pain, hypoproteinemia and edema. Laboratory tests showed that the boy was infected with Clostridium difficile (CD). Gastrointestinal endoscopy revealed giant gastric folds, and histological gastric biopsies showed foveolar hyperplasia with glandular atrophy, infiltration of eosinophils in the lamina propria of the patient. Finally, the boy was recovered after supportive therapy with intravenous albumin and CD eradication.

Conclusion: For the nonspecific clinical symptoms of MD, gastrointestinal endoscopic evaluations with gastric tissue biopsies are required to establish the diagnosis of MD in children with unexplained hypoalbuminemia.

Keywords: Child; Hypertrophy; Hypoalbuminemia; Ménétrier’s disease.

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Conflict of interest statement

The authors declare that they have no competing interests.

Figures

Fig. 1
Fig. 1
Abdominal computed tomography (CT) images obtained with intravenous Ominpaque showing giant cerebriform enlargement of rugal folds in the gastric fundus and body
Fig. 2
Fig. 2
Gastrointestinal endoscopy images showing enlarged gastric rugal folds, erythema, and hemorrhagic erosions in the gastric body
Fig. 3
Fig. 3
Histological images (H&E, × 100) showing foveolar hyperplasia with glandular atrophy, infiltration of eosinophils, plasmocytes and neutrophils in the lamina propria
See this image and copyright information in PMC

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