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Randomized Controlled Trial
. 2020 Mar 5;20(1):86.
doi: 10.1186/s12886-020-01359-3.

Effect of dexmedetomidine on prevention of postoperative nausea and vomiting in pediatric strabismus surgery: a randomized controlled study

Shuangshuang Li  1 , Tingjie Liu  1 , Junming Xia  1 , Jie Jia  2 , Wenxian Li  3
Affiliations
Randomized Controlled Trial

Effect of dexmedetomidine on prevention of postoperative nausea and vomiting in pediatric strabismus surgery: a randomized controlled study

Shuangshuang Li et al. BMC Ophthalmol. .

Abstract

Background: Postoperative nausea and vomiting (PONV) are common side-effects following strabismus surgery. The present study aimed to compare the effects of different doses of dexmedetomidine (DEX) on PONV incidence in pediatric patients undergoing strabismus surgery.

Methods: In this prospective randomized double-blinded study, 126 pediatric patients undergoing strabismus surgery were randomized into one of three groups: Placebo group, normal saline; DEX1 group, 0.3 μg/kg dexmedetomidine, and DEX2 group, 0.5 μg/kg dexmedetomidine. Oculocardiac reflex (OCR) events were recorded during surgery. PONV or postoperative vomiting (POV) was recorded for 24 h in the ward. Pediatric anesthesia emergence delirium (PAED) scale and emergence agitation (EA) scale were recorded in the recovery room.

Results: Intraoperative OCR was significantly reduced in DEX2 group (42%) as compared to that of Placebo group (68%) (p = 0.0146). During the first 24 h post-op, the overall incidence of PONV was significantly lower in DEX2 group (10%) than that of Placebo group (32%) (p = 0.0142). There was no significant difference in POV among the three groups. PAED or EA scores among the three groups were similar during recovery time.

Conclusion: Dexmedetomidine (0.5 μg/kg) reduced OCR and PONV without lengthening extubation time or recovery time in pediatric patients undergoing strabismus surgery.

Trial registration: The trial was prospectively registered before patient enrollment at Chinese Clinical Trial Registry (Clinical Trial Number: ChiCTR1800020176, Date: 12/19/2018).

Keywords: Dexmedetomidine; Emergence agitation; Oculocardiac reflex; Postoperative nausea and vomiting; Strabismus surgery.

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Conflict of interest statement

The authors declare that they have no competing interests.

Figures

Fig. 1
Fig. 1
Postoperative agitation and pain profile. EA = emergence agitation; PAED = Pediatric Anesthesia Emergence Delirium; VRS: visual rating scale; T0: removing the LMA; T1: 5 min after removing the LMA; T2: 10 min after removing the LMA; T3: 15 min after removing the LMA; T00: out of PACU; T11: 4 h after operation; T22: 12 h after operation; T33: 24 h after operation
See this image and copyright information in PMC

References

    1. Höhne C. Postoperative nausea and vomiting in pediatric anesthesia. Curr Opin Anaesthesiol. 2014;27(3):303–308. doi: 10.1097/ACO.0000000000000073. - DOI - PubMed
    1. Eberhart LH, Geldner G, Kranke P, Morin AM, Schäuffelen A, Treiber H, Wulf H. The development and validation of a risk score to predict the probability of postoperative vomiting in pediatric patients. Anesth Analg. 2004;99(6):1630–1637. doi: 10.1213/01.ANE.0000135639.57715.6C. - DOI - PubMed
    1. Joo J, Park S, Park HJ, Shin SY. Ramosetron versus ondansetron for postoperative nausea and vomiting in strabismus surgery patients. BMC Anesthesiol. 2016;16(1):41. doi: 10.1186/s12871-016-0210-5. - DOI - PMC - PubMed
    1. Habib AS, Gan TJ. Evidence-based management of postoperative nausea and vomiting: a review. Can J Anaesth. 2004;51(4):326–341. doi: 10.1007/BF03018236. - DOI - PubMed
    1. Madan R, Bhatia A, Chakithandy S, Subramaniam R, Rammohan G, Deshpande S, Singh M, Kaul HL. Prophylactic dexamethasone for postoperative nausea and vomiting in pediatric strabismus surgery: a dose ranging and safety evaluation study. Anesth Analg. 2005;100(6):1622–1626. doi: 10.1213/01.ANE.0000150977.14607.E1. - DOI - PubMed

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