Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2020 Mar;33(1):101145.
doi: 10.1016/j.beha.2020.101145. Epub 2020 Jan 11.

Reconstructing the evolutionary history of multiple myeloma

Francesco Maura  1 , Even H Rustad  2 , Eileen M Boyle  3 , Gareth J Morgan  4
Affiliations
Review

Reconstructing the evolutionary history of multiple myeloma

Francesco Maura et al. Best Pract Res Clin Haematol. 2020 Mar.

Abstract

Multiple myeloma is the second most common lymphoproliferative disorder, characterized by aberrant expansion of monoclonal plasma cells. In the last years, thanks to novel next generation sequencing technologies, multiple myeloma has emerged as one of the most complex hematological cancers, shaped over time by the activity of multiple mutational processes and by the acquisition of key driver events. In this review, we describe how whole genome sequencing is emerging as a key technology to decipher this complexity at every stage of myeloma development: precursors, diagnosis and relapsed/refractory. Defining the time windows when driver events are acquired improves our understanding of cancer etiology and paves the way for early diagnosis and ultimately prevention.

Keywords: Driver events; Multiple myeloma; Timing; Whole genome sequencing.

PubMed Disclaimer

Conflict of interest statement

Declaration of competing interest No conflict of interests to declare.

Figures

Figure 1.
Figure 1.
Multiple myeloma pathogenetic model.
Figure 2.
Figure 2.
Three classed of complex events observed in multiple myeloma.
Figure 3.
Figure 3.
The methodological workflow to reconstruct the chronological order of driver events in multiple myeloma.
Figure 4.
Figure 4.
Multiple myeloma mutational signature landscape. The 96-classes mutational profile from exome (a, CoMMpass) and genome data (b).
See this image and copyright information in PMC

References

    1. Corre J, Munshi N, Avet-Loiseau H. Genetics of multiple myeloma: another heterogeneity level? Blood. 2015;125(12):1870–6. - PMC - PubMed
    1. Manier S, Salem KZ, Park J, Landau DA, Getz G, Ghobrial IM. Genomic complexity of multiple myeloma and its clinical implications. Nat Rev Clin Oncol. 2017;14(2):100–13. - PubMed
    1. Morgan GJ, Walker BA, Davies FE. The genetic architecture of multiple myeloma. Nat Rev Cancer. 2012;12(5):335–48. - PubMed
    1. Kyle RA, Rajkumar SV. Monoclonal gammopathy of undetermined significance and smoldering multiple myeloma. Hematol Oncol Clin North Am. 2007;21(6):1093–113, ix. - PubMed
    1. Landgren O, Kyle RA, Pfeiffer RM, Katzmann JA, Caporaso NE, Hayes RB, et al. Monoclonal gammopathy of undetermined significance (MGUS) consistently precedes multiple myeloma: a prospective study. Blood. 2009;113(22):5412–7. - PMC - PubMed

Publication types

MeSH terms