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. 2020 May;97(1):114998.
doi: 10.1016/j.diagmicrobio.2020.114998. Epub 2020 Jan 27.

Intestinal carriage of colistin resistant Enterobacteriaceae in hospitalized patients from an Indian center

Gnana Soundari Palani  1 , Abdul Ghafur  2 , Padma Krishnan  3 , B Rayvathy  4 , M A Thirunarayan  5
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Intestinal carriage of colistin resistant Enterobacteriaceae in hospitalized patients from an Indian center

Gnana Soundari Palani et al. Diagn Microbiol Infect Dis. 2020 May.

Abstract

There is limited data on the gut colonization rate of colistin resistant (Col-R) bacteria in patients and healthy volunteers in India. Aim of this study was to investigate the stool carriage rate of Col-R in hospitalized patients. Stool samples were inoculated in Eosin Methylene Blue agar plates supplemented with colistin. Colistin minimum inhibitory concentrations (MICs) were determined by the broth microdilution method. PCR for the mcr-1 was performed on Col-R Enterobacteriaceae isolates. Mutations in the mgrB gene were analyzed in K. pneumoniae isolates. Mcr-1 positive E. coli was subjected to whole-genome sequencing. Out of 65 stool samples screened, 33 (51%) samples carried Col-R bacteria. Majority (76.7%) of the isolates were sensitive to carbapenem.

Keywords: Colistin resistance; IncX4 plasmid; Mcr-1; mgrB.

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