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. 2020 May;97(1):114997.
doi: 10.1016/j.diagmicrobio.2020.114997. Epub 2020 Jan 25.

Intact pap2 downstream of mcr-1 appears to be required for colistin resistance

Yujin Choi  1 , Ji-Young Lee  1 , Suk-Kyung Lim  2 , Kwan Soo Ko  3
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Intact pap2 downstream of mcr-1 appears to be required for colistin resistance

Yujin Choi et al. Diagn Microbiol Infect Dis. 2020 May.

Abstract

In this study, we investigated the effect of pap2 on colistin susceptibility using intact pap2 and truncated pap2 (pap2∆351) genes, which were found along with mcr-1 in plasmid. Our experiments based on conjugation, antibiotic susceptibility testing, and time-killing assay showed that an intact pap2 gene is necessary along with mcr-1 for reduced colistin susceptibility.

Keywords: Colistin resistance; mcr-1; pap2.

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