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Comment
. 2020 Mar 5;26(3):299-301.
doi: 10.1016/j.stem.2020.02.009.

Divide and Rule: Mitochondrial Fission Regulates Quiescence in Hematopoietic Stem Cells

Tiago C Luis  1 , Hannah Lawson  2 , Kamil R Kranc  3
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Divide and Rule: Mitochondrial Fission Regulates Quiescence in Hematopoietic Stem Cells

Tiago C Luis et al. Cell Stem Cell. .
Free article

Abstract

Hematopoietic stem cells (HSCs) remain quiescent to preserve long-term integrity. In this issue of Cell Stem Cell, Hinge et al. (2020) and Liang et al. (2020) demonstrate that HSCs achieve this by regulating mitochondrial fission and lysosomal activity, suppressing glucose uptake, and maintaining healthy punctate mitochondria with low metabolic activity.

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