Tackling the Many Facets of Glioblastoma Heterogeneity

Itay Tirosh¹, Mario L Suvà²

Affiliations

¹ Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot 761001, Israel. Electronic address: itay.tirosh@weizmann.ac.il.
² Department of Pathology and Center for Cancer Research, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA; Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA. Electronic address: suva.mario@mgh.harvard.edu.

PMID: 32142659
DOI: 10.1016/j.stem.2020.02.005

Free article

Comment

Tackling the Many Facets of Glioblastoma Heterogeneity

Itay Tirosh et al. Cell Stem Cell. 2020.

Free article

. 2020 Mar 5;26(3):303-304.

doi: 10.1016/j.stem.2020.02.005.

Authors

Itay Tirosh¹, Mario L Suvà²

Affiliations

¹ Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot 761001, Israel. Electronic address: itay.tirosh@weizmann.ac.il.
² Department of Pathology and Center for Cancer Research, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA; Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA. Electronic address: suva.mario@mgh.harvard.edu.

PMID: 32142659
DOI: 10.1016/j.stem.2020.02.005

Abstract

Glioblastoma is an incurable brain tumor notorious for its heterogeneity. Recent studies in Cell (Jacob et al., 2020) and Cell Stem Cell (Bhaduri et al., 2020) leverage novel glioblastoma organoid models and single-cell RNA-sequencing technologies to tackle glioblastoma's heterogeneous nature, providing new tools and insights into tumor biology.

PubMed Disclaimer

Comment on

A Patient-Derived Glioblastoma Organoid Model and Biobank Recapitulates Inter- and Intra-tumoral Heterogeneity.
Jacob F, Salinas RD, Zhang DY, Nguyen PTT, Schnoll JG, Wong SZH, Thokala R, Sheikh S, Saxena D, Prokop S, Liu DA, Qian X, Petrov D, Lucas T, Chen HI, Dorsey JF, Christian KM, Binder ZA, Nasrallah M, Brem S, O'Rourke DM, Ming GL, Song H. Jacob F, et al. Cell. 2020 Jan 9;180(1):188-204.e22. doi: 10.1016/j.cell.2019.11.036. Epub 2019 Dec 26. Cell. 2020. PMID: 31883794 Free PMC article.
Outer Radial Glia-like Cancer Stem Cells Contribute to Heterogeneity of Glioblastoma.
Bhaduri A, Di Lullo E, Jung D, Müller S, Crouch EE, Espinosa CS, Ozawa T, Alvarado B, Spatazza J, Cadwell CR, Wilkins G, Velmeshev D, Liu SJ, Malatesta M, Andrews MG, Mostajo-Radji MA, Huang EJ, Nowakowski TJ, Lim DA, Diaz A, Raleigh DR, Kriegstein AR. Bhaduri A, et al. Cell Stem Cell. 2020 Jan 2;26(1):48-63.e6. doi: 10.1016/j.stem.2019.11.015. Cell Stem Cell. 2020. PMID: 31901251 Free PMC article.

Publication types

Actions

MeSH terms

Actions
Actions
Actions
Actions
Actions
Actions

LinkOut - more resources

Full Text Sources
- Elsevier Science
Medical
- MedlinePlus Health Information

Save citation to file

Email citation

Add to Collections

Add to My Bibliography

Your saved search

Create a file for external citation management software

Your RSS Feed

Tackling the Many Facets of Glioblastoma Heterogeneity

Affiliations

Tackling the Many Facets of Glioblastoma Heterogeneity

Authors

Affiliations

Abstract

Comment on

Publication types

MeSH terms

LinkOut - more resources

Full Text Sources

Medical