Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2020 Mar 5;180(5):822-824.
doi: 10.1016/j.cell.2020.02.025.

Boosting Cytotoxic Antibodies against Cancer

Laurent Gauthier  1 , Eric Vivier  2
Affiliations
Free article
Comment

Boosting Cytotoxic Antibodies against Cancer

Laurent Gauthier et al. Cell. .
Free article

Abstract

Monoclonal antibodies (mAbs) targeting antigens expressed at the surface of tumor cells are widely used for cancer control in clinics, but these treatments need to be improved. Chew et al. show how an old drug, prochlorperazine, could be repurposed to enhance the efficacy of anti-tumor mAbs by increasing the cell-surface expression of tumor antigens.

PubMed Disclaimer

Conflict of interest statement

Declaration of Interests L.G. and E.V. are employees of Innate Pharma.

Comment on

  • Endocytosis Inhibition in Humans to Improve Responses to ADCC-Mediating Antibodies.
    Chew HY, De Lima PO, Gonzalez Cruz JL, Banushi B, Echejoh G, Hu L, Joseph SR, Lum B, Rae J, O'Donnell JS, Merida de Long L, Okano S, King B, Barry R, Moi D, Mazzieri R, Thomas R, Souza-Fonseca-Guimaraes F, Foote M, McCluskey A, Robinson PJ, Frazer IH, Saunders NA, Parton RG, Dolcetti R, Cuff K, Martin JH, Panizza B, Walpole E, Wells JW, Simpson F. Chew HY, et al. Cell. 2020 Mar 5;180(5):895-914.e27. doi: 10.1016/j.cell.2020.02.019. Cell. 2020. PMID: 32142680

Publication types

LinkOut - more resources