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Comment
. 2020 Mar 5;180(5):829-831.
doi: 10.1016/j.cell.2020.02.024.

Renewing the Fight Against TB with an Old Vaccine

Thomas J Scriba  1 , Valerie Mizrahi  2
Affiliations
Free article
Comment

Renewing the Fight Against TB with an Old Vaccine

Thomas J Scriba et al. Cell. .
Free article

Abstract

Prevention of pulmonary tuberculosis by vaccination has proven an elusive goal. In a recent study, Darrah et al. show that prevention of infection and disease can be achieved in non-human primates by intravenous administration of the century-old vaccine BCG. This finding heralds a step-change in the approach to TB vaccine development.

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  • Prevention of tuberculosis in macaques after intravenous BCG immunization.
    Darrah PA, Zeppa JJ, Maiello P, Hackney JA, Wadsworth MH 2nd, Hughes TK, Pokkali S, Swanson PA 2nd, Grant NL, Rodgers MA, Kamath M, Causgrove CM, Laddy DJ, Bonavia A, Casimiro D, Lin PL, Klein E, White AG, Scanga CA, Shalek AK, Roederer M, Flynn JL, Seder RA. Darrah PA, et al. Nature. 2020 Jan;577(7788):95-102. doi: 10.1038/s41586-019-1817-8. Epub 2020 Jan 1. Nature. 2020. PMID: 31894150 Free PMC article.

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