Evidence for Gastrointestinal Infection of SARS-CoV-2

Fei Xiao¹, Meiwen Tang², Xiaobin Zheng³, Ye Liu⁴, Xiaofeng Li⁵, Hong Shan⁶

Affiliations

¹ Department of Infectious Diseases, the Fifth Affiliated Hospital, Sun Yat-sen University, Zhuhai, Guangdong Province, China; Guangdong Provincial Engineering Research Center of Molecular Imaging, the Fifth Affiliated Hospital, Sun Yat-sen University, Zhuhai, Guangdong Province, China; Guangdong Provincial Key Laboratory of Biomedical Imaging, the Fifth Affiliated Hospital, Sun Yat-sen University, Zhuhai, Guangdong Province, China.
² Department of Hematology, the Fifth Affiliated Hospital, Sun Yat-sen University, Zhuhai, Guangdong Province, China.
³ Department of Respiratory and Critical Care Medicine, the Fifth Affiliated Hospital, Sun Yat-sen University, Zhuhai, Guangdong Province, China.
⁴ Department of Pathology, the Fifth Affiliated Hospital, Sun Yat-sen University, Zhuhai, Guangdong Province, China. Electronic address: ly77219@163.com.
⁵ Department of Gastroenterology, the Fifth Affiliated Hospital, Sun Yat-sen University, Zhuhai, Guangdong Province, China. Electronic address: zdwylxf@163.com.
⁶ Guangdong Provincial Engineering Research Center of Molecular Imaging, the Fifth Affiliated Hospital, Sun Yat-sen University, Zhuhai, Guangdong Province, China; Guangdong Provincial Key Laboratory of Biomedical Imaging, the Fifth Affiliated Hospital, Sun Yat-sen University, Zhuhai, Guangdong Province, China; Department of Interventional Medicine, the Fifth Affiliated Hospital, Sun Yat-sen University, Zhuhai, Guangdong Province, China. Electronic address: shanhong@mail.sysu.edu.cn.

PMID: 32142773
PMCID: PMC7130181
DOI: 10.1053/j.gastro.2020.02.055

Comment

Evidence for Gastrointestinal Infection of SARS-CoV-2

Fei Xiao et al. Gastroenterology. 2020 May.

. 2020 May;158(6):1831-1833.e3.

doi: 10.1053/j.gastro.2020.02.055. Epub 2020 Mar 3.

Authors

Fei Xiao¹, Meiwen Tang², Xiaobin Zheng³, Ye Liu⁴, Xiaofeng Li⁵, Hong Shan⁶

Affiliations

¹ Department of Infectious Diseases, the Fifth Affiliated Hospital, Sun Yat-sen University, Zhuhai, Guangdong Province, China; Guangdong Provincial Engineering Research Center of Molecular Imaging, the Fifth Affiliated Hospital, Sun Yat-sen University, Zhuhai, Guangdong Province, China; Guangdong Provincial Key Laboratory of Biomedical Imaging, the Fifth Affiliated Hospital, Sun Yat-sen University, Zhuhai, Guangdong Province, China.
² Department of Hematology, the Fifth Affiliated Hospital, Sun Yat-sen University, Zhuhai, Guangdong Province, China.
³ Department of Respiratory and Critical Care Medicine, the Fifth Affiliated Hospital, Sun Yat-sen University, Zhuhai, Guangdong Province, China.
⁴ Department of Pathology, the Fifth Affiliated Hospital, Sun Yat-sen University, Zhuhai, Guangdong Province, China. Electronic address: ly77219@163.com.
⁵ Department of Gastroenterology, the Fifth Affiliated Hospital, Sun Yat-sen University, Zhuhai, Guangdong Province, China. Electronic address: zdwylxf@163.com.
⁶ Guangdong Provincial Engineering Research Center of Molecular Imaging, the Fifth Affiliated Hospital, Sun Yat-sen University, Zhuhai, Guangdong Province, China; Guangdong Provincial Key Laboratory of Biomedical Imaging, the Fifth Affiliated Hospital, Sun Yat-sen University, Zhuhai, Guangdong Province, China; Department of Interventional Medicine, the Fifth Affiliated Hospital, Sun Yat-sen University, Zhuhai, Guangdong Province, China. Electronic address: shanhong@mail.sysu.edu.cn.

PMID: 32142773
PMCID: PMC7130181
DOI: 10.1053/j.gastro.2020.02.055

No abstract available

Keywords: ACE2; Gastrointestinal Infection; Oral-Fecal Transmission; SARS-CoV-2.

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Figures

**Figure 1**
Images of histologic and immunofluorescent staining of gastrointestinal tissues. Shown are images of histologic and immunofluorescent staining of esophagus, stomach, duodenum, and rectum. The scale bar in the histologic image represents 100 μm. The scale bar in the immunofluorescent image represents 20 μm.

See this image and copyright information in PMC

Comment in

Fighting the Battle against SARS-CoV-2 as Gastroenterologists in Italy.
Pagnini C, Urgesi R, Di Paolo MC, Graziani MG. Pagnini C, et al. Gastroenterology. 2020 Oct;159(4):1619. doi: 10.1053/j.gastro.2020.03.067. Epub 2020 Apr 2. Gastroenterology. 2020. PMID: 32247691 Free PMC article. No abstract available.
Fecal-Oral Transmission of SARS-COV-2: Practical Implications.
Bonato G, Dioscoridi L, Mutignani M. Bonato G, et al. Gastroenterology. 2020 Oct;159(4):1621-1622. doi: 10.1053/j.gastro.2020.03.066. Epub 2020 Apr 2. Gastroenterology. 2020. PMID: 32247692 Free PMC article. No abstract available.
Why Does SARS-CoV-2 Invade the Gastrointestinal Epithelium?
Uno Y. Uno Y. Gastroenterology. 2020 Oct;159(4):1622-1623. doi: 10.1053/j.gastro.2020.04.006. Epub 2020 Apr 10. Gastroenterology. 2020. PMID: 32283099 Free PMC article. No abstract available.
SARS-CoV-2-Induced Vomiting as Onset Symptom in a Patient with COVID-19.
Fu B, Qian K, Fu X. Fu B, et al. Dig Dis Sci. 2020 Jun;65(6):1568-1570. doi: 10.1007/s10620-020-06285-4. Epub 2020 Apr 28. Dig Dis Sci. 2020. PMID: 32347435 Free PMC article. No abstract available.
Gastrointestinal ACE2, COVID-19 and IBD: Opportunity in the Face of Tragedy?
Garg M, Christensen B, Lubel JS. Garg M, et al. Gastroenterology. 2020 Oct;159(4):1623-1624.e3. doi: 10.1053/j.gastro.2020.04.051. Epub 2020 Apr 27. Gastroenterology. 2020. PMID: 32353370 Free PMC article. No abstract available.
[Dosing physical exercise intensity during the COVlD-19 quarantine: Does perceptual self-regulation work in children?].
Rodríguez-Núñez I. Rodríguez-Núñez I. Rev Chil Pediatr. 2020 Apr;91(2):304-305. doi: 10.32641/rchped.vi91i2.2208. Rev Chil Pediatr. 2020. PMID: 32730554 Spanish. No abstract available.
Presence of SARS-Coronavirus-2 in the Ileal Mucosa: Another Evidence for Infection of GI Tract by This Virus.
El Hajra Martínez I, Relea Pérez L, Calvo Moya M. El Hajra Martínez I, et al. Gastroenterology. 2020 Oct;159(4):1624-1625. doi: 10.1053/j.gastro.2020.05.101. Epub 2020 Aug 7. Gastroenterology. 2020. PMID: 32777284 Free PMC article. No abstract available.

Comment on

First Case of 2019 Novel Coronavirus in the United States.
Holshue ML, DeBolt C, Lindquist S, Lofy KH, Wiesman J, Bruce H, Spitters C, Ericson K, Wilkerson S, Tural A, Diaz G, Cohn A, Fox L, Patel A, Gerber SI, Kim L, Tong S, Lu X, Lindstrom S, Pallansch MA, Weldon WC, Biggs HM, Uyeki TM, Pillai SK; Washington State 2019-nCoV Case Investigation Team. Holshue ML, et al. N Engl J Med. 2020 Mar 5;382(10):929-936. doi: 10.1056/NEJMoa2001191. Epub 2020 Jan 31. N Engl J Med. 2020. PMID: 32004427 Free PMC article.

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Evidence for Gastrointestinal Infection of SARS-CoV-2

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Evidence for Gastrointestinal Infection of SARS-CoV-2

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