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Review
. 2020 Mar 6;19(1):34.
doi: 10.1186/s12944-020-01220-y.

Caspase-1 as a regulatory molecule of lipid metabolism

Meseret Derbew Molla  1 , Birhanu Ayelign  2 , Gashaw Dessie  3 , Zeleke Geto  4 , Tesfahun Dessale Admasu  3
Affiliations
Review

Caspase-1 as a regulatory molecule of lipid metabolism

Meseret Derbew Molla et al. Lipids Health Dis. .

Abstract

Caspase-1 is an evolutionarily conserved inflammatory mediated enzyme that cleaves and activates inflammatory cytokines. It can be activated through the assembly of inflammasome and its major effect is to activate the pro-inflammatory cytokines; interleukin 1β (IL-1β) and interluekine-18 (IL-18). In addition to IL-1β and IL-8, several lines of evidence showed that caspase-1 targets the substrates that are involved in different metabolic pathways, including lipid metabolism. Caspase-1 regulates lipid metabolism through cytokine dependent or cytokine independent regulation of genes that involved in lipid metabolism and its regulation. To date, there are several reports on the role of caspase-1 in lipid metabolism. Therefore, this review is aimed to summarize the role of caspase-1 in lipid metabolism and its regulation.

Keywords: Caspase-1; Inflammasome; Lipid metabolism; Transcriptional factors.

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Conflict of interest statement

The authors declare that they have no any competing interest.

Figures

Fig. 1
Fig. 1
effect of caspase-1 in lipid metabolism.
See this image and copyright information in PMC

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