Effects of six months of aerobic and resistance training on metabolic markers and bone mineral density in older men on androgen deprivation therapy for prostate cancer

Affiliations

¹ Faculty of Kinesiology and Physical Education, University of Toronto, Toronto, ON M5S 2W6, Canada; Department of Supportive Care, University Health Network, Toronto, ON M5G 2C4, Canada. Electronic address: efthymios.papadopoulos@mail.utoronto.ca.
² Faculty of Kinesiology and Physical Education, University of Toronto, Toronto, ON M5S 2W6, Canada; Department of Supportive Care, University Health Network, Toronto, ON M5G 2C4, Canada.
³ Faculty of Kinesiology, University of Calgary, Calgary, AB T2N 1N4, Canada.
⁴ Department of Supportive Care, University Health Network, Toronto, ON M5G 2C4, Canada.
⁵ York University, Toronto, ON M3J 1P3, Canada.
⁶ Faculty of Kinesiology and Physical Education, University of Toronto, Toronto, ON M5S 2W6, Canada.
⁷ Institute of Health Policy, Management and Evaluation, University of Toronto, Toronto ON M5S 1A1, Canada; Faculty of Medicine, University of Toronto, Toronto ON M5S 1A8, Canada; Toronto General Hospital Research Institute, University Health Network, Toronto, ON M5G 2C4, Canada.
⁸ Institute of Health Policy, Management and Evaluation, University of Toronto, Toronto ON M5S 1A1, Canada.
⁹ Cancer Clinical Research Unit, University Health Network, Toronto, ON M5G 2C1, Canada; Faculty of Medicine, University of Toronto, Toronto ON M5S 1A8, Canada.
¹⁰ Cancer Clinical Research Unit, University Health Network, Toronto, ON M5G 2C1, Canada.
¹¹ Department of Supportive Care, University Health Network, Toronto, ON M5G 2C4, Canada; Institute of Health Policy, Management and Evaluation, University of Toronto, Toronto ON M5S 1A1, Canada; Faculty of Medicine, University of Toronto, Toronto ON M5S 1A8, Canada.

PMID: 32143995
DOI: 10.1016/j.jgo.2020.02.013

Randomized Controlled Trial

Effects of six months of aerobic and resistance training on metabolic markers and bone mineral density in older men on androgen deprivation therapy for prostate cancer

Efthymios Papadopoulos et al. J Geriatr Oncol. 2020 Sep.

. 2020 Sep;11(7):1074-1077.

doi: 10.1016/j.jgo.2020.02.013. Epub 2020 Mar 3.

Authors

Affiliations

¹ Faculty of Kinesiology and Physical Education, University of Toronto, Toronto, ON M5S 2W6, Canada; Department of Supportive Care, University Health Network, Toronto, ON M5G 2C4, Canada. Electronic address: efthymios.papadopoulos@mail.utoronto.ca.
² Faculty of Kinesiology and Physical Education, University of Toronto, Toronto, ON M5S 2W6, Canada; Department of Supportive Care, University Health Network, Toronto, ON M5G 2C4, Canada.
³ Faculty of Kinesiology, University of Calgary, Calgary, AB T2N 1N4, Canada.
⁴ Department of Supportive Care, University Health Network, Toronto, ON M5G 2C4, Canada.
⁵ York University, Toronto, ON M3J 1P3, Canada.
⁶ Faculty of Kinesiology and Physical Education, University of Toronto, Toronto, ON M5S 2W6, Canada.
⁷ Institute of Health Policy, Management and Evaluation, University of Toronto, Toronto ON M5S 1A1, Canada; Faculty of Medicine, University of Toronto, Toronto ON M5S 1A8, Canada; Toronto General Hospital Research Institute, University Health Network, Toronto, ON M5G 2C4, Canada.
⁸ Institute of Health Policy, Management and Evaluation, University of Toronto, Toronto ON M5S 1A1, Canada.
⁹ Cancer Clinical Research Unit, University Health Network, Toronto, ON M5G 2C1, Canada; Faculty of Medicine, University of Toronto, Toronto ON M5S 1A8, Canada.
¹⁰ Cancer Clinical Research Unit, University Health Network, Toronto, ON M5G 2C1, Canada.
¹¹ Department of Supportive Care, University Health Network, Toronto, ON M5G 2C4, Canada; Institute of Health Policy, Management and Evaluation, University of Toronto, Toronto ON M5S 1A1, Canada; Faculty of Medicine, University of Toronto, Toronto ON M5S 1A8, Canada.

PMID: 32143995
DOI: 10.1016/j.jgo.2020.02.013

Abstract

Background: Androgen deprivation therapy (ADT) for prostate cancer (PCa) is associated with metabolic perturbations and declines in bone mineral density (BMD). Exercise interventions provide multiple health benefits to older men on ADT; however, their effect on metabolic biomarkers and BMD remains unclear.

Methods: A secondary analysis of a phase II randomized controlled trial was conducted to assess the effect of a six-month moderate-intensity aerobic and resistance exercise program on metabolic biomarkers and BMD in men on ADT. Participants were randomized to three different exercise delivery models: personal training; supervised group exercise; or home-based exercise. Analysis of metabolic biomarkers (lipid profile and glucose) was conducted at baseline, six and twelve months. BMD of the lumbar spine, femoral neck and hip were assessed at baseline and twelve months. Both within- and between-group analyses of change scores adjusted for baseline values were performed.

Results: Forty-eight men (mean age 69.8y) were enrolled. Baseline values of metabolic biomarkers and BMD were comparable between groups and the three groups were combined for the primary analysis. At six months, no changes in metabolic biomarkers were found; however, at twelve months low-density lipoprotein (+0.28 mmol/L; 95%CI, 0.04 to 0.51) and total cholesterol (+0.31 mmol/L; 95%CI, 0.00 to 0.61) were significantly increased from baseline. No changes were found in BMD. In a secondary between-group analysis, no improvements were observed for any metabolic biomarker or BMD measurement.

Conclusions: Different exercise prescription parameters (modality and intensity) or combined diet/exercise interventions may be needed to foster favorable metabolic and skeletal adaptations during ADT.

Keywords: Androgen deprivation therapy; Bone mineral density; Exercise; Metabolic biomarkers; Prostate cancer.

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Declaration of Competing Interest The authors have no conflicts of interest to disclose.

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Effects of six months of aerobic and resistance training on metabolic markers and bone mineral density in older men on androgen deprivation therapy for prostate cancer

Affiliations

Effects of six months of aerobic and resistance training on metabolic markers and bone mineral density in older men on androgen deprivation therapy for prostate cancer

Authors

Affiliations

Abstract

Conflict of interest statement

Publication types

MeSH terms

Substances

LinkOut - more resources

Full Text Sources

Medical