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Comment
. 2020 May;10(5):635.
doi: 10.1158/2159-8290.CD-RW2020-035. Epub 2020 Mar 6.

New Drug-Discovery Assay Identifies Novel Mutant-EGFR Inhibitors

No authors listed
Comment

New Drug-Discovery Assay Identifies Novel Mutant-EGFR Inhibitors

No authors listed. Cancer Discov. 2020 May.

Abstract

The MaMTH-DS assay detected inhibitors of mutant EGFR in non-small cell lung cancer cells.

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  • A drug discovery platform to identify compounds that inhibit EGFR triple mutants.
    Saraon P, Snider J, Kalaidzidis Y, Wybenga-Groot LE, Weiss K, Rai A, Radulovich N, Drecun L, Vučković N, Vučetić A, Wong V, Thériault B, Pham NA, Park JH, Datti A, Wang J, Pathmanathan S, Aboualizadeh F, Lyakisheva A, Yao Z, Wang Y, Joseph B, Aman A, Moran MF, Prakesch M, Poda G, Marcellus R, Uehling D, Samaržija M, Jakopović M, Tsao MS, Shepherd FA, Sacher A, Leighl N, Akhmanova A, Al-Awar R, Zerial M, Stagljar I. Saraon P, et al. Nat Chem Biol. 2020 May;16(5):577-586. doi: 10.1038/s41589-020-0484-2. Epub 2020 Feb 24. Nat Chem Biol. 2020. PMID: 32094923 Free PMC article.

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