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Comment
. 2020 May;10(5):OF10.
doi: 10.1158/2159-8290.CD-RW2020-036. Epub 2020 Mar 6.

Epigenetic Therapy Can Suppress Premetastatic Changes in the Lung

No authors listed
Comment

Epigenetic Therapy Can Suppress Premetastatic Changes in the Lung

No authors listed. Cancer Discov. 2020 May.

Abstract

Low-dose adjuvant epigenetic therapy (AET) reduced metastasis and promoted survival in mouse models.

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  • Epigenetic therapy inhibits metastases by disrupting premetastatic niches.
    Lu Z, Zou J, Li S, Topper MJ, Tao Y, Zhang H, Jiao X, Xie W, Kong X, Vaz M, Li H, Cai Y, Xia L, Huang P, Rodgers K, Lee B, Riemer JB, Day CP, Yen RC, Cui Y, Wang Y, Wang Y, Zhang W, Easwaran H, Hulbert A, Kim K, Juergens RA, Yang SC, Battafarano RJ, Bush EL, Broderick SR, Cattaneo SM, Brahmer JR, Rudin CM, Wrangle J, Mei Y, Kim YJ, Zhang B, Wang KK, Forde PM, Margolick JB, Nelkin BD, Zahnow CA, Pardoll DM, Housseau F, Baylin SB, Shen L, Brock MV. Lu Z, et al. Nature. 2020 Mar;579(7798):284-290. doi: 10.1038/s41586-020-2054-x. Epub 2020 Feb 26. Nature. 2020. PMID: 32103175 Free PMC article.

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