Identification of the hyper-variable genomic hotspot for the novel coronavirus SARS-CoV-2

doi:10.1016/j.jinf.2020.02.027

Comment

. 2020 Jun;80(6):671-693.

doi: 10.1016/j.jinf.2020.02.027. Epub 2020 Mar 5.

Identification of the hyper-variable genomic hotspot for the novel coronavirus SARS-CoV-2

Feng Wen¹, Hai Yu², Jinyue Guo³, Yong Li⁴, Kaijian Luo⁵, Shujian Huang⁶

Affiliations

¹ College of Life Science and Engineering, Foshan University, Foshan, 528231 Guangdong, China. Electronic address: wenfengjlu@163.com.
² Shanghai Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Shanghai 200241, China; Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou 225009, China.
³ College of Life Science and Engineering, Foshan University, Foshan, 528231 Guangdong, China.
⁴ College of Animal Science and Technology, Jiangxi Agricultural University, Nanchang 330045 Jiangxi, China.
⁵ College of Veterinary Medicine, South China Agricultural University, Guangzhou 510642 Guangdong, China.
⁶ College of Life Science and Engineering, Foshan University, Foshan, 528231 Guangdong, China. Electronic address: 617955368@qq.com.

PMID: 32145215
PMCID: PMC7126159
DOI: 10.1016/j.jinf.2020.02.027

Comment

Identification of the hyper-variable genomic hotspot for the novel coronavirus SARS-CoV-2

Feng Wen et al. J Infect. 2020 Jun.

. 2020 Jun;80(6):671-693.

doi: 10.1016/j.jinf.2020.02.027. Epub 2020 Mar 5.

Authors

Feng Wen¹, Hai Yu², Jinyue Guo³, Yong Li⁴, Kaijian Luo⁵, Shujian Huang⁶

Affiliations

¹ College of Life Science and Engineering, Foshan University, Foshan, 528231 Guangdong, China. Electronic address: wenfengjlu@163.com.
² Shanghai Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Shanghai 200241, China; Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou 225009, China.
³ College of Life Science and Engineering, Foshan University, Foshan, 528231 Guangdong, China.
⁴ College of Animal Science and Technology, Jiangxi Agricultural University, Nanchang 330045 Jiangxi, China.
⁵ College of Veterinary Medicine, South China Agricultural University, Guangzhou 510642 Guangdong, China.
⁶ College of Life Science and Engineering, Foshan University, Foshan, 528231 Guangdong, China. Electronic address: 617955368@qq.com.

PMID: 32145215
PMCID: PMC7126159
DOI: 10.1016/j.jinf.2020.02.027

No abstract available

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Conflict of interest statement

Declaration of Competing Interest None.

Figures

Fig 1 — **Fig. 1**
(A) The similarity between SARS-CoV-2 and other beta coronaviruses using the sliding window showed that SARS-CoV-2 was similar to bat virus RaTG13. (B) The molecular phylogenetic tree based on protein sequences established the high similarity among SARS-CoV-2 and its near relatives. (C) The mutations that developed after it came to circulate among humans did not include any mutation with high occurrence. (D) The graphs show all of the differences between SARS-CoV-2 and its close relative strains isolated from bats.

See this image and copyright information in PMC

Comment on

The continuous evolution and dissemination of 2019 novel human coronavirus.
Zhang J, Ma K, Li H, Liao M, Qi W. Zhang J, et al. J Infect. 2020 Jun;80(6):671-693. doi: 10.1016/j.jinf.2020.02.001. Epub 2020 Feb 22. J Infect. 2020. PMID: 32092385 Free PMC article. No abstract available.

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References

1. Zhang J., Ma K., Li H., Liao M., Qi W. The continuous evolution and dissemination of 2019 novel human coronavirus. J. Infect. 2020 - PMC - PubMed
1. Wu A., Peng Y., Huang B., Ding X., Wang X., Niu P. Genome composition and divergence of the novel coronavirus (2019-nCoV) originating in China. Cell Host Microbe. 2020 - PMC - PubMed
1. Wu F., Zhao S., Yu B., Chen YM., Wang W., Song. Z.G. A new coronavirus associated with human respiratory disease in china. Nature. 2020 - PMC - PubMed
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1. Shu Y., McCauley J. GISAID: global initiative on sharing all influenza data - from vision to reality. Euro. Surveill. 2017;22(13) - PMC - PubMed

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[1] Zhang J., Ma K., Li H., Liao M., Qi W. The continuous evolution and dissemination of 2019 novel human coronavirus. J. Infect. 2020 - PMC - PubMed

[2] Zhang J., Ma K., Li H., Liao M., Qi W. The continuous evolution and dissemination of 2019 novel human coronavirus. J. Infect. 2020 - PMC - PubMed

[3] Wu A., Peng Y., Huang B., Ding X., Wang X., Niu P. Genome composition and divergence of the novel coronavirus (2019-nCoV) originating in China. Cell Host Microbe. 2020 - PMC - PubMed

[4] Wu A., Peng Y., Huang B., Ding X., Wang X., Niu P. Genome composition and divergence of the novel coronavirus (2019-nCoV) originating in China. Cell Host Microbe. 2020 - PMC - PubMed

[5] Wu F., Zhao S., Yu B., Chen YM., Wang W., Song. Z.G. A new coronavirus associated with human respiratory disease in china. Nature. 2020 - PMC - PubMed

[6] Wu F., Zhao S., Yu B., Chen YM., Wang W., Song. Z.G. A new coronavirus associated with human respiratory disease in china. Nature. 2020 - PMC - PubMed

[7] Zhou P., Yang X.L., Wang X.G., Hu B., Zhang L., Zhang W. A pneumonia outbreak associated with a new coronavirus of probable bat origin. Nature. 2020 - PMC - PubMed

[8] Zhou P., Yang X.L., Wang X.G., Hu B., Zhang L., Zhang W. A pneumonia outbreak associated with a new coronavirus of probable bat origin. Nature. 2020 - PMC - PubMed

[9] Shu Y., McCauley J. GISAID: global initiative on sharing all influenza data - from vision to reality. Euro. Surveill. 2017;22(13) - PMC - PubMed

[10] Shu Y., McCauley J. GISAID: global initiative on sharing all influenza data - from vision to reality. Euro. Surveill. 2017;22(13) - PMC - PubMed

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Identification of the hyper-variable genomic hotspot for the novel coronavirus SARS-CoV-2

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Identification of the hyper-variable genomic hotspot for the novel coronavirus SARS-CoV-2

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