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Review
. 2020 Mar;37(3):193-196.
doi: 10.1016/j.rmr.2020.02.005. Epub 2020 Mar 4.

[Characterisation of the protective role of erythropoetin in a murine model of acute lung injury]

[Article in French]
C H Yegen  1 , L Haine  1 , D Marchant  1 , E Boncoeur  2 , N Voituron  3
Affiliations
Review

[Characterisation of the protective role of erythropoetin in a murine model of acute lung injury]

[Article in French]
C H Yegen et al. Rev Mal Respir. 2020 Mar.

Abstract

In addition to its role in erythropoiesis, erythropoietin (Epo) plays a role in tissue protection, which includes cardioprotective, nephroprotective and neuroprotective effects. The presence of Epo and its receptor (Epo-R) in pulmonary tissue also suggests a cytoprotective effect of Epo in the lung. Our project aims to document this role in a murine model under-expressing Epo. The obtained results will lead to a better understanding of the cytoprotective effects of Epo and will also give an appreciation of its beneficial effects in cases of lung injury.

Keywords: Agressions pulmonaire; Cytoprotection; Erythropoietin; Erythropoïétine; Lung injury.

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