. 2020 Jun;8(6):1953-1960.e9.

doi: 10.1016/j.jaip.2020.01.059. Epub 2020 Mar 4.

Research Priorities in Pediatric Asthma: Results of a Global Survey of Multiple Stakeholder Groups by the Pediatric Asthma in Real Life (PeARL) Think Tank

Alexander G Mathioudakis¹, Adnan Custovic², Antoine Deschildre³, Francine M Ducharme⁴, Omer Kalayci⁵, Clare Murray¹, Antonio Nieto Garcia⁶, Wanda Phipatanakul⁷, David Price⁸, Aziz Sheikh⁹, Ioana Agache¹⁰, Leonard Bacharier¹¹, Matteo Bonini¹², Jose A Castro-Rodriguez¹³, Giuseppe De Carlo¹⁴, Timothy Craig¹⁵, Zuzana Diamant¹⁶, Wojciech Feleszko¹⁷, Despo Ierodiakonou¹⁸, James E Gern¹⁹, Jonathan Grigg²⁰, Gunilla Hedlin²¹, Elham M Hossny²², Tuomas Jartti²³, Alan Kaplan²⁴, Robert F Lemanske¹⁹, Peter Le Souef²⁵, Mika J Makela²⁶, Paolo M Matricardi²⁷, Michael Miligkos²⁸, Mário Morais-Almeida²⁹, Helena Pite³⁰, Paulo M C Pitrez³¹, Petr Pohunek³², Graham Roberts³³, Sylvia Sanchez-Garcia³⁴, Ioanna Tsiligianni¹⁸, Steve Turner³⁵, Tonya A Winders³⁶, Gary Wong³⁷, Paraskevi Xepapadaki³⁸, Heather J Zar³⁹, Nikolaos G Papadopoulos⁴⁰

Affiliations

¹ Division of Infection, Immunity and Respiratory Medicine, School of Biological Sciences, The University of Manchester, Manchester, United Kingdom; North West Lung Centre, Wythenshawe Hospital, Manchester University NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester, United Kingdom.
² Department of Paediatrics, Imperial College London, London, United Kingdom.
³ CHU Lille, Université Nord de France, Unité de Pneumologie et Allergologie Pédiatriques, Hôpital Jeanne de Flandre, Lille, France.
⁴ Department of Pediatrics, University of Montreal, Montreal, QC, Canada.
⁵ Pediatric Allergy and Asthma Unit, Hacettepe University School of Medicine, Ankara, Turkey.
⁶ Pulmonology and Allergy Unity, University Hospital La Fe, Valencia, Spain.
⁷ Pediatric Allergy and Immunology, Children's Hospital Boston, Boston, Mass.
⁸ Centre of Academic Primary Care, Division of Applied Health Sciences, University of Aberdeen, Aberdeen, United Kingdom; Observational and Pragmatic Research Institute, Singapore.
⁹ Asthma UK Centre for Applied Research, Usher Institute of Population Health Sciences and Informatics, The University of Edinburgh, Edinburgh, United Kingdom.
¹⁰ Faculty of Medicine, Transylvania University, Brasov, Romania.
¹¹ Division of Allergy, Immunology, and Pulmonary Medicine, Department of Pediatrics, Washington University, St. Louis, Mo.
¹² Department of Cardiovascular and Thoracic Sciences, Catholic University of the Sacred Heart, Fondazione Policlinico Universitario "A. Gemelli" - IRCCS, Rome, Italy; National Heart and Lung Institute (NHLI), Imperial College London, London, United Kingdom.
¹³ Department of Pediatrics, School of Medicine, Pontifical Universidad Catolica de Chile, Santiago, Chile.
¹⁴ European Federation of Allergy and Airway Diseases Patient's Associations, Brussels, Belgium.
¹⁵ Department of Medicine and Pediatrics, Penn State University, Hershey, Pa.
¹⁶ Department of Respiratory Medicine and Allergology, Institute for Clinical Science, Skane University Hospital, Lund University, Lund, Sweden; Department of Respiratory Medicine, First Faculty of Medicine, Charles University and Thomayer Hospital, Prague, Czech Republic; Department of Clinical Pharmacy & Pharmacology, University of Groningen, University Medical Center of Groningen and QPS-NL, Groningen, the Netherlands.
¹⁷ Department of Pediatric Pulmonology and Allergy, The Medical University Children's Hospital, Warszawa, Poland.
¹⁸ Health Planning Unit, Department of Social Medicine, Faculty of Medicine, University of Crete, Crete, Greece.
¹⁹ Department of Pediatrics and Medicine, University of Wisconsin School of Medicine and Public Health, Madison, Wis.
²⁰ Centre for Genomics and Child Health, Blizard Institute, Queen Mary University of London, London, United Kingdom.
²¹ Department of Women's and Children's Health, Karolinska Institutet, Stockholm, Sweden.
²² Pediatric Allergy and Immunology Unit, Children's Hospital, Ain Shams University, Cairo, Egypt.
²³ Department of Paediatrics, Turku University Hospital and University of Turku, Turku, Finland.
²⁴ Family Physician Airways Group of Canada, University of Toronto, Toronto, ON, Canada.
²⁵ School of Paediatrics and Child Health, University of Western Australia, Perth, Australia.
²⁶ Department of Allergy, Helsinki University Skin and Allergy Hospital and University of Helsinki, Helsinki, Finland.
²⁷ Department of Pediatric Pulmonology, Immunology and Intensive Care Medicine, Charité - University Medicine Berlin, Berlin, Germany.
²⁸ Division of Pediatric Pulmonology, First Department of Pediatrics, National and Kapodistrian University of Athens School of Medicine and Aghia Sophia Children's Hospital, Athens, Greece.
²⁹ Allergy Center, CUF Descobertas Hospital, Lisbon, Portugal.
³⁰ Allergy Center, CUF Descobertas Hospital, Lisbon, Portugal; Allergy Center, CUF Infante Santo Hospital, Lisbon, Portugal; Chronic Diseases Research Center (CEDOC), NOVA Medical School/Faculdade de Ciências Médicas, Universidade NOVA de Lisboa, Lisbon, Portugal.
³¹ Laboratory of Respiratory Physiology, Infant Center, School of Medicine, Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS), Porto Alegre, Brazil.
³² Paediatric Department, Second Faculty of Medicine, Charles University and Motol University Hospital, Prague, Czech Republic.
³³ The David Hide Asthma and Allergy Research Centre, St Mary's Hospital, Newport Isle of Wight, United Kingdom; Faculty of Medicine, Clinical and Experimental Sciences and Human Development in Health Academic Units, University of Southampton, Southampton, United Kingdom; NIHR Biomedical Research Centre, University Hospital Southampton NHS Foundation Trust, Southampton, United Kingdom.
³⁴ Allergy Department, Hospital Infantil Universitario Niño Jesús, Madrid, Spain.
³⁵ Child Health, Royal Aberdeen Children's Hospital and University of Aberdeen, Aberdeen, United Kingdom.
³⁶ Allergy and Asthma Network, Vienna, Va; Global Allergy and Asthma Patient Platform, Vienna, Austria.
³⁷ Department of Paediatrics, Faculty of Medicine, The Chinese University of Hong Kong, Sha Tin, Hong Kong.
³⁸ Allergy Department, 2nd Paediatric Clinic, National and Kapodistrian University of Athens, Athens, Greece.
³⁹ Department of Paediatrics and Child Health, Red Cross Children's Hospital and SA-Medical Research Council Unit on Child and Adolescent Health, University of Cape Town, Cape Town, South Africa.
⁴⁰ Division of Infection, Immunity and Respiratory Medicine, School of Biological Sciences, The University of Manchester, Manchester, United Kingdom; Allergy Department, 2nd Paediatric Clinic, National and Kapodistrian University of Athens, Athens, Greece. Electronic address: ngpallergy@gmail.com.

PMID: 32146166
DOI: 10.1016/j.jaip.2020.01.059

Research Priorities in Pediatric Asthma: Results of a Global Survey of Multiple Stakeholder Groups by the Pediatric Asthma in Real Life (PeARL) Think Tank

Alexander G Mathioudakis et al. J Allergy Clin Immunol Pract. 2020 Jun.

. 2020 Jun;8(6):1953-1960.e9.

doi: 10.1016/j.jaip.2020.01.059. Epub 2020 Mar 4.

Authors

Affiliations

¹ Division of Infection, Immunity and Respiratory Medicine, School of Biological Sciences, The University of Manchester, Manchester, United Kingdom; North West Lung Centre, Wythenshawe Hospital, Manchester University NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester, United Kingdom.
² Department of Paediatrics, Imperial College London, London, United Kingdom.
³ CHU Lille, Université Nord de France, Unité de Pneumologie et Allergologie Pédiatriques, Hôpital Jeanne de Flandre, Lille, France.
⁴ Department of Pediatrics, University of Montreal, Montreal, QC, Canada.
⁵ Pediatric Allergy and Asthma Unit, Hacettepe University School of Medicine, Ankara, Turkey.
⁶ Pulmonology and Allergy Unity, University Hospital La Fe, Valencia, Spain.
⁷ Pediatric Allergy and Immunology, Children's Hospital Boston, Boston, Mass.
⁸ Centre of Academic Primary Care, Division of Applied Health Sciences, University of Aberdeen, Aberdeen, United Kingdom; Observational and Pragmatic Research Institute, Singapore.
⁹ Asthma UK Centre for Applied Research, Usher Institute of Population Health Sciences and Informatics, The University of Edinburgh, Edinburgh, United Kingdom.
¹⁰ Faculty of Medicine, Transylvania University, Brasov, Romania.
¹¹ Division of Allergy, Immunology, and Pulmonary Medicine, Department of Pediatrics, Washington University, St. Louis, Mo.
¹² Department of Cardiovascular and Thoracic Sciences, Catholic University of the Sacred Heart, Fondazione Policlinico Universitario "A. Gemelli" - IRCCS, Rome, Italy; National Heart and Lung Institute (NHLI), Imperial College London, London, United Kingdom.
¹³ Department of Pediatrics, School of Medicine, Pontifical Universidad Catolica de Chile, Santiago, Chile.
¹⁴ European Federation of Allergy and Airway Diseases Patient's Associations, Brussels, Belgium.
¹⁵ Department of Medicine and Pediatrics, Penn State University, Hershey, Pa.
¹⁶ Department of Respiratory Medicine and Allergology, Institute for Clinical Science, Skane University Hospital, Lund University, Lund, Sweden; Department of Respiratory Medicine, First Faculty of Medicine, Charles University and Thomayer Hospital, Prague, Czech Republic; Department of Clinical Pharmacy & Pharmacology, University of Groningen, University Medical Center of Groningen and QPS-NL, Groningen, the Netherlands.
¹⁷ Department of Pediatric Pulmonology and Allergy, The Medical University Children's Hospital, Warszawa, Poland.
¹⁸ Health Planning Unit, Department of Social Medicine, Faculty of Medicine, University of Crete, Crete, Greece.
¹⁹ Department of Pediatrics and Medicine, University of Wisconsin School of Medicine and Public Health, Madison, Wis.
²⁰ Centre for Genomics and Child Health, Blizard Institute, Queen Mary University of London, London, United Kingdom.
²¹ Department of Women's and Children's Health, Karolinska Institutet, Stockholm, Sweden.
²² Pediatric Allergy and Immunology Unit, Children's Hospital, Ain Shams University, Cairo, Egypt.
²³ Department of Paediatrics, Turku University Hospital and University of Turku, Turku, Finland.
²⁴ Family Physician Airways Group of Canada, University of Toronto, Toronto, ON, Canada.
²⁵ School of Paediatrics and Child Health, University of Western Australia, Perth, Australia.
²⁶ Department of Allergy, Helsinki University Skin and Allergy Hospital and University of Helsinki, Helsinki, Finland.
²⁷ Department of Pediatric Pulmonology, Immunology and Intensive Care Medicine, Charité - University Medicine Berlin, Berlin, Germany.
²⁸ Division of Pediatric Pulmonology, First Department of Pediatrics, National and Kapodistrian University of Athens School of Medicine and Aghia Sophia Children's Hospital, Athens, Greece.
²⁹ Allergy Center, CUF Descobertas Hospital, Lisbon, Portugal.
³⁰ Allergy Center, CUF Descobertas Hospital, Lisbon, Portugal; Allergy Center, CUF Infante Santo Hospital, Lisbon, Portugal; Chronic Diseases Research Center (CEDOC), NOVA Medical School/Faculdade de Ciências Médicas, Universidade NOVA de Lisboa, Lisbon, Portugal.
³¹ Laboratory of Respiratory Physiology, Infant Center, School of Medicine, Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS), Porto Alegre, Brazil.
³² Paediatric Department, Second Faculty of Medicine, Charles University and Motol University Hospital, Prague, Czech Republic.
³³ The David Hide Asthma and Allergy Research Centre, St Mary's Hospital, Newport Isle of Wight, United Kingdom; Faculty of Medicine, Clinical and Experimental Sciences and Human Development in Health Academic Units, University of Southampton, Southampton, United Kingdom; NIHR Biomedical Research Centre, University Hospital Southampton NHS Foundation Trust, Southampton, United Kingdom.
³⁴ Allergy Department, Hospital Infantil Universitario Niño Jesús, Madrid, Spain.
³⁵ Child Health, Royal Aberdeen Children's Hospital and University of Aberdeen, Aberdeen, United Kingdom.
³⁶ Allergy and Asthma Network, Vienna, Va; Global Allergy and Asthma Patient Platform, Vienna, Austria.
³⁷ Department of Paediatrics, Faculty of Medicine, The Chinese University of Hong Kong, Sha Tin, Hong Kong.
³⁸ Allergy Department, 2nd Paediatric Clinic, National and Kapodistrian University of Athens, Athens, Greece.
³⁹ Department of Paediatrics and Child Health, Red Cross Children's Hospital and SA-Medical Research Council Unit on Child and Adolescent Health, University of Cape Town, Cape Town, South Africa.
⁴⁰ Division of Infection, Immunity and Respiratory Medicine, School of Biological Sciences, The University of Manchester, Manchester, United Kingdom; Allergy Department, 2nd Paediatric Clinic, National and Kapodistrian University of Athens, Athens, Greece. Electronic address: ngpallergy@gmail.com.

PMID: 32146166
DOI: 10.1016/j.jaip.2020.01.059

Abstract

Background: Pediatric asthma remains a public health challenge with enormous impact worldwide.

Objective: The aim of this study was to identify and prioritize unmet clinical needs in pediatric asthma, which could be used to guide future research and policy activities.

Methods: We first identified unmet needs through an open-question survey administered to international experts in pediatric asthma who were members of the Pediatric Asthma in Real Life Think Tank. Prioritization of topics was then achieved through a second, extensive survey with global reach, of multiple stakeholders (leading experts, researchers, clinicians, patients, policy makers, and the pharmaceutical industry). Differences across responder groups were compared.

Results: A total of 57 unmet clinical need topics identified by international experts were prioritized by 412 participants from 5 continents and 60 countries. Prevention of disease progression and prediction of future risk, including persistence into adulthood, emerged as the most urgent research questions. Stratified care, based on biomarkers, clinical phenotypes, the children's age, and demographics were also highly rated. The identification of minimum diagnostic criteria in different age groups, cultural perceptions of asthma, and best treatment by age group were priorities for responders from low-middle-income countries. There was good agreement across different stakeholder groups in all domains with some notable exceptions that highlight the importance of involving the whole range of stakeholders in formulation of recommendations.

Conclusions: Different stakeholders agree in the majority of research and strategic (eg, prevention, personalized approach) priorities for pediatric asthma. Stakeholder diversity is crucial for highlighting divergent issues that future guidelines should consider.

Keywords: Assessment; Asthma; Childhood asthma; Clinical research; Diagnosis; Management; Pediatric asthma; Research priorities.

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Research Priorities in Pediatric Asthma: Results of a Global Survey of Multiple Stakeholder Groups by the Pediatric Asthma in Real Life (PeARL) Think Tank

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Research Priorities in Pediatric Asthma: Results of a Global Survey of Multiple Stakeholder Groups by the Pediatric Asthma in Real Life (PeARL) Think Tank

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