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Review
. 2020 Apr;31(2):191-200.
doi: 10.1016/j.nec.2019.11.001. Epub 2020 Jan 24.

Hybrid Therapy for Spinal Metastases

Robert Rothrock  1 , Zach Pennington  2 , Jeff Ehresman  2 , Mark H Bilsky  3 , Ori Barzilai  3 , Nicholas J Szerlip  4 , Daniel M Sciubba  5
Affiliations
Review

Hybrid Therapy for Spinal Metastases

Robert Rothrock et al. Neurosurg Clin N Am. 2020 Apr.

Abstract

The combination of separation surgery and stereotactic body radiotherapy optimizes the treatment of metastatic spine tumors. The integration of SBRT into treatment paradigms produces superb local control rates and consequently has diminished the role of surgery from principle treatment to one of adjuvant therapy. Under this paradigm, hybrid therapy for the treatment of metastatic spine tumors employs separation surgery to decompress the spinal cord and stabilize the spine while creating a safe target for ablative SBRT. Hybrid therapy is well tolerated, allows an early return to systemic therapy, and provides durable, local tumor control compared with more aggressive traditional approaches.

Keywords: Hybrid therapy; Metastases; Radiation; Radiosurgery; Separation surgery; Spinal cord; Spine; Tumor.

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Conflict of interest statement

Disclosure Dr M.H. Bilsky receives consulting fees from DePuy/Synthes, Globus, and Brainla; Dr O. Barzilai: fellowship support to his institution from Globus for work performed outside of the current study; Dr D.M. Sciubba: Consultant for Baxter, DePuy-Synthes, Globus Medical, K2M, Medtronic, NuVasive. Unrelated grant funding from Baxter, North American Spine Society, Stryker. Drs R. Rothrock, Z. Pennington, J. Ehresman and N.J. Szerlip have nothing to dosclose.

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