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Review
. 2021 May;19(5):876-884.
doi: 10.1016/j.cgh.2020.02.054. Epub 2020 Mar 6.

Burden of Pancreatic Cancer: From Epidemiology to Practice

Natalia Khalaf  1 , Hashem B El-Serag  2 , Hannah R Abrams  3 , Aaron P Thrift  4
Affiliations
Review

Burden of Pancreatic Cancer: From Epidemiology to Practice

Natalia Khalaf et al. Clin Gastroenterol Hepatol. 2021 May.

Abstract

Pancreatic cancer is the seventh leading cause of cancer-related deaths worldwide with 432,242 related deaths in 2018. Unlike other cancers, the incidence of pancreatic cancer continues to increase, with little improvement in survival rates. We review the epidemiologic features of pancreatic cancer, covering surveillance and early detection in high-risk persons. We summarize data on worldwide incidence and mortality and analyze the 1975-2016 data from 9 registries of the National Cancer Institute's Surveillance, Epidemiology, and End Results study, on the overall burden of pancreatic cancer as well as age-, sex-, and race-specific incidence, survival rates and trends. It is important to increase our knowledge of the worldwide and regional epidemiologic features of and risk factors for pancreatic cancer, to identify new approaches for prevention, surveillance, and treatment.

Keywords: PDAC; Pancreatic Adenocarcinoma; Prevalence; SEER Program.

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Conflict of interest statement

Conflicts of interest: No relevant conflicts of interest exist.

Figures

Figure 1:
Figure 1:
Trends in age-standardized incidence rates for pancreatic cancer in the United States between 1975 and 2016. Source: SEER 9 registries.
Figure 2:
Figure 2:
Trends in age-standardized incidence rates for (A) prostate cancer (men only), (B) breast cancer (women only), (C) lung cancer and (D) colorectal cancer in the United States between 1975 and 2016. Source: SEER 9 registries.
Figure 2:
Figure 2:
Trends in age-standardized incidence rates for (A) prostate cancer (men only), (B) breast cancer (women only), (C) lung cancer and (D) colorectal cancer in the United States between 1975 and 2016. Source: SEER 9 registries.
Figure 2:
Figure 2:
Trends in age-standardized incidence rates for (A) prostate cancer (men only), (B) breast cancer (women only), (C) lung cancer and (D) colorectal cancer in the United States between 1975 and 2016. Source: SEER 9 registries.
Figure 2:
Figure 2:
Trends in age-standardized incidence rates for (A) prostate cancer (men only), (B) breast cancer (women only), (C) lung cancer and (D) colorectal cancer in the United States between 1975 and 2016. Source: SEER 9 registries.
Figure 3:
Figure 3:
Stage distribution of incident cases of pancreatic cancer in the United States between 1975 and 2016. Source: SEER 9 registries.
Figure 4:
Figure 4:
One and five year relative survival rates for patients with pancreatic cancer in the United States between 2007 and 2011 by stage at diagnosis. Source: SEER 9 registries.
Figure 5:
Figure 5:
One and five year relative survival rates for patients with pancreatic cancer in the United States between 2007 and 2011 by race and stage at diagnosis. Source: SEER 9 registries.
See this image and copyright information in PMC

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