Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Case Reports
. 2020 Feb 22:2020:6562896.
doi: 10.1155/2020/6562896. eCollection 2020.

Early Recognition and Treatment of Malignant Hyperthermia in Pediatric Patient during Bronchoscopy

Warangkana Lapisatepun  1 , Supawan Arkarattanakul  2
Affiliations
Case Reports

Early Recognition and Treatment of Malignant Hyperthermia in Pediatric Patient during Bronchoscopy

Warangkana Lapisatepun et al. Case Rep Anesthesiol. .

Abstract

Malignant hyperthermia is a rare pharmacogenetic disorder triggered by depolarizing muscle relaxant and potent volatile anesthetic agents. An MH crisis is an emergency and life-threatening event requiring early recognition and prompt management. Dantrolene is the specific antagonist of MH. The authors report the case of a 9-year-old boy who underwent an emergency bronchoscopy to remove a foreign body and developed masseter rigidity after succinylcholine and sevoflurane exposure. The anesthesia team diagnosed an MH event, and the event was managed immediately with supportive treatment, dantrolene, being administered within 10 minutes. The patient survived and had a good outcome without any complications. We suggest that it is essential for anesthesia providers to recognize the need for intraoperative vigilance, prompt recognition, and treatment, and dantrolene sodium should be readily available in every hospital.

PubMed Disclaimer

Conflict of interest statement

The authors declare that they have no conflicts of interest.

Similar articles

See all similar articles

References

    1. Rosenberg H., Pollock N., Schiemann A., Bulger T., Stowell K. Malignant hyperthermia: a review. Orphanet Journal of Rare Diseases. 2015;10(1):p. 93. doi: 10.1186/s13023-015-0310-1. - DOI - PMC - PubMed
    1. Brady J. E., Sun L. S., Rosenberg H., Li G. Prevalence of malignant hyperthermia due to anesthesia in New York State, 2001–2005. Anesthesia & Analgesia. 2009;109(4):1162–1166. doi: 10.1213/ane.0b013e3181ac1548. - DOI - PubMed
    1. Larach M. G., Gronert G. A., Allen G. C., Brandom B. W., Lehman E. B. Clinical presentation, treatment, and complications of malignant hyperthermia in North America from 1987 to 2006. Anesthesia & Analgesia. 2010;110(2):498–507. doi: 10.1213/ane.0b013e3181c6b9b2. - DOI - PubMed
    1. Halliday N. J. Malignant hyperthermia. Journal of Craniofacial Surgery. 2003;14(5):800–802. doi: 10.1097/00001665-200309000-00039. - DOI - PubMed
    1. Rosenberg H., Brandom B. W. B., Sambuughin S. Malignant hyperthermia and other inherited disorders. In: Barash P. G., Cullen B. F., Stoelting R. K., Cahalan M. K., Stock M. C., editors. Clinical Anesthesia. Sixth. Philadelphia, PA, USA: Lippincott Williams & Wilkins; 2009. pp. 598–621.

Publication types

LinkOut - more resources