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. 2020 Feb 20:2020:2475301.
doi: 10.1155/2020/2475301. eCollection 2020.

Bredemolic Acid Ameliorates Selected Liver Function Biomarkers in a Diet-Induced Prediabetic Rat Model

Akinjide Moses Akinnuga  1 , Angezwa Siboto  1 , Bongiwe Khumalo  1 , Ntethelelo Hopewell Sibiya  2 , Phikelelani Ngubane  1 , Andile Khathi  1
Affiliations

Bredemolic Acid Ameliorates Selected Liver Function Biomarkers in a Diet-Induced Prediabetic Rat Model

Akinjide Moses Akinnuga et al. Can J Gastroenterol Hepatol. .

Abstract

Background: Prediabetes is an intermediary hyperglycaemic state that precedes type 2 diabetes mellitus (T2DM) in which abnormal metabolism of glucose and lipids occurs in organs such as the liver. Evidence has shown that, about 70% of T2DM patients develop hepatic dysfunction which is found to begin during the prediabetic stage. Bredemolic acid, a pentacyclic triterpene, has been found to improve insulin sensitivity in diet-induced prediabetic rats. The effects of this compound on liver function, however, are unknown. This study was therefore designed to investigate the effects of BA on liver function in high fat-high carbohydrate (HFHC) diet-induced prediabetic rats.

Methods: Thirty-six (36) male rats that weigh 150 g-180 g were divided into two groups, the non-prediabetic (n = 6) and the prediabetic groups (n = 6) and the prediabetic groups (n = 6) and the prediabetic groups (.

Results: The induction of prediabetes resulted in increased release of liver enzymes (AST and ALT), increased liver glycogen and triglyceride, lipid peroxidation, and decreased sterol regulatory element-binding protein (SREBP1c) and antioxidant enzymes. However, the administration of BA decreased liver enzyme concentrations, decreased hepatic oxidative stress, and improved antioxidant enzymes such as SOD and GPx.

Conclusion: BA administration improved liver function in diet-induced prediabetic rats in the presence or absence of dietary intervention.

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Conflict of interest statement

The authors declare no conflicts of interest.

Figures

Figure 1
Figure 1
Effects of BA with the presence or absence of dietary intervention on the relative liver weight in prediabetic rats. ∗p < 0.05 in comparison with NPD; #p < 0.001 in comparison with PD.
Figure 2
Figure 2
Effects of BA with the presence or absence of dietary intervention on the plasma AST and ALT in prediabetic rats. ∗p < 0.001 in comparison with NPD; #p < 0.05 in comparison with PD.
Figure 3
Figure 3
Effects of BA with the presence or absence of dietary intervention on the liver SREBP1c in prediabetic rats. ∗p < 0.001 in comparison with NPD, #p < 0.001 in comparison with PD, and ^p < 0.01 in comparison with HFHC + MET.
Figure 4
Figure 4
Effects of BA with the presence or absence of dietary intervention on the liver triglyceride in prediabetic rats. ∗p < 0.001 in comparison with NPD; #p < 0.001 in comparison with PD.
Figure 5
Figure 5
Effects of BA with the presence or absence of dietary intervention on the liver glycogen in prediabetic rats. ∗p < 0.001 in comparison with NPD; #p < 0.001 in comparison with PD.
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