Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2020 Feb 19:2020:6910312.
doi: 10.1155/2020/6910312. eCollection 2020.

RANKL/RANK/OPG Pathway: A Mechanism Involved in Exercise-Induced Bone Remodeling

Mohammad Tobeiha  1 , Mohammed H Moghadasian  2 , Negin Amin  1 , Sadegh Jafarnejad  1
Affiliations
Review

RANKL/RANK/OPG Pathway: A Mechanism Involved in Exercise-Induced Bone Remodeling

Mohammad Tobeiha et al. Biomed Res Int. .

Abstract

Bones as an alive organ consist of about 70% mineral and 30% organic component. About 200 million people are suffering from osteopenia and osteoporosis around the world. There are multiple ways of protecting bone from endogenous and exogenous risk factors. Planned physical activity is another useful way for protecting bone health. It has been investigated that arranged exercise would effectively regulate bone metabolism. Until now, a number of systems have discovered how exercise could help bone health. Previous studies reported different mechanisms of the effect of exercise on bone health by modulation of bone remodeling. However, the regulation of RANKL/RANK/OPG pathway in exercise and physical performance as one of the most important remodeling systems is not considered comprehensive in previous evidence. Therefore, the aim of this review is to clarify exercise influence on bone modeling and remodeling, with a concentration on its role in regulating RANKL/RANK/OPG pathway.

PubMed Disclaimer

Conflict of interest statement

The authors declare that there are no conflicts of interest regarding the publication of the present manuscript.

Figures

Figure 1
Figure 1
Interaction of exercise and RANKL/RANK/OPG biomolecular pathway. OPG: osteoprotegerin; RANK: receptor activator of nuclear factor κB; RANKL: receptor activator of NF-kB ligand.
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Vannucci L. Calcium intake in bone health: a focus on calcium-rich mineral waters. Nutrients. 2018;10(12) doi: 10.3390/nu10121930. - DOI - PMC - PubMed
    1. Boyce B. F., Xing L. Biology of RANK, RANKL, and osteoprotegerin. Arthritis Research & Therapy. 2007;9(Suppl 1):p. S1. doi: 10.1186/ar2165. - DOI - PMC - PubMed
    1. Cooper C., Campion G., Melton L. J., III Hip fractures in the elderly: a world-wide projection. Osteoporosis International. 1992;2(6):285–289. doi: 10.1007/bf01623184. - DOI - PubMed
    1. Seem S. A., Yuan Y. V., Tou J. C. Chocolate and chocolate constituents influence bone health and osteoporosis risk. Nutrition. 2019;65:74–84. doi: 10.1016/j.nut.2019.02.011. - DOI - PubMed
    1. Datta H. K., Ng W. F., Walker J. A., Tuck S. P., Varanasi S. S. The cell biology of bone metabolism. Journal of Clinical Pathology. 2008;61(5):577–587. doi: 10.1136/jcp.2007.048868. - DOI - PubMed

LinkOut - more resources