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Case Reports
. 2020 Feb 19;6(3):214-216.
doi: 10.1016/j.jdcr.2020.01.006. eCollection 2020 Mar.

Malignant circumscribed acral hypokeratosis

Lorin A Bibb  1 , James P Rash  2 , Roy King  3   4
Affiliations
Case Reports

Malignant circumscribed acral hypokeratosis

Lorin A Bibb et al. JAAD Case Rep. .
No abstract available

Keywords: Bowen disease; CAH; CAH, circumscribed acral hypokeratosis; circumscribed acral hypokeratosis; circumscribed palmoplantar hypokeratosis; circumscribed plantar hypokeratosis; malignant transformation; squamous cell carcinoma in situ.

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Figures

Fig 1
Fig 1
Circumscribed acral hypokeratosis. A well-demarcated, erythematous patch with a peripheral hyperkeratotic border surrounding a central area of atrophy and focal crusting. To the periphery of the primary lesion is a secondary patch of erythematous depressed skin with central crusting.
Fig 2
Fig 2
Circumscribed acral hypokeratosis histopathology. A region of normal acral epidermis with orthokeratosis before an abrupt decline in the thickness of the stratum corneum, with a frayed edge of stratum corneum at the distinct transition point. The subsequent depressed region revealed hypokeratosis, parakeratosis, and hypogranulosis. (Hematoxylin-eosin stain.)
Fig 3
Fig 3
Squamous cell carcinoma in situ superimposed on circumscribed acral hypokeratosis. Within the zone of hypokeratosis, there is full-thickness epidermal keratinocyte atypia and loss of orderly maturation, consistent with squamous cell carcinoma in situ. (Hematoxylin-eosin stain.)
See this image and copyright information in PMC

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References

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