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Case Reports
. 2020 Feb 19;6(3):214-216.
doi: 10.1016/j.jdcr.2020.01.006. eCollection 2020 Mar.

Malignant circumscribed acral hypokeratosis

Lorin A Bibb  1 , James P Rash  2 , Roy King  3   4
Affiliations
Case Reports

Malignant circumscribed acral hypokeratosis

Lorin A Bibb et al. JAAD Case Rep. .
No abstract available

Keywords: Bowen disease; CAH; CAH, circumscribed acral hypokeratosis; circumscribed acral hypokeratosis; circumscribed palmoplantar hypokeratosis; circumscribed plantar hypokeratosis; malignant transformation; squamous cell carcinoma in situ.

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Figures

Fig 1
Fig 1
Circumscribed acral hypokeratosis. A well-demarcated, erythematous patch with a peripheral hyperkeratotic border surrounding a central area of atrophy and focal crusting. To the periphery of the primary lesion is a secondary patch of erythematous depressed skin with central crusting.
Fig 2
Fig 2
Circumscribed acral hypokeratosis histopathology. A region of normal acral epidermis with orthokeratosis before an abrupt decline in the thickness of the stratum corneum, with a frayed edge of stratum corneum at the distinct transition point. The subsequent depressed region revealed hypokeratosis, parakeratosis, and hypogranulosis. (Hematoxylin-eosin stain.)
Fig 3
Fig 3
Squamous cell carcinoma in situ superimposed on circumscribed acral hypokeratosis. Within the zone of hypokeratosis, there is full-thickness epidermal keratinocyte atypia and loss of orderly maturation, consistent with squamous cell carcinoma in situ. (Hematoxylin-eosin stain.)
See this image and copyright information in PMC

References

    1. Pérez A., Rütten A., Gold R. Circumscribed palmar or plantar hypokeratosis: a distinctive epidermal malformation of the palms or soles. J Am Acad Dermatol. 2002;47(1):21–27. - PubMed
    1. Resnik K.S., DiLeonardo M. Circumscribed palmar hypokeratosis: new observations. Am J Dermatopathol. 2006;28(2):112–116. - PubMed
    1. Nakai K., Yoneda K., Moriue J., Moriue T., Kubota Y. Hypokeratosis of multiple Bowen’s disease of the palms. Dermatol Sin. 2017;35(2):100–101.
    1. Böer A., Falk T.M. Circumscribed palmar hypokeratosis induced by papilloma virus type 4. J Am Acad Dermatol. 2006;54(5):908–909. - PubMed
    1. Berk D.R., Böer A., Bauschard F.D., Hurt M.A., Santa-Cruz D.J., Eisen A.Z. Circumscribed acral hypokeratosis. J Am Acad Dermatol. 2007;57(2):292–296. - PubMed

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