Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Meta-Analysis
. 2020 May 1;93(1109):20190847.
doi: 10.1259/bjr.20190847. Epub 2020 Mar 18.

Diagnostic accuracy of Doppler ultrasound, CT and MRI in Budd Chiari syndrome: systematic review and meta-analysis

Pankaj Gupta  1 , Varun Bansal  1 , Praveen Kumar-M  2 , Saroj K Sinha  3 , Jayanta Samanta  3 , Harshal Mandavdhare  3 , Vishal Sharma  3 , Usha Dutta  3 , Rakesh Kochhar  3
Affiliations
Meta-Analysis

Diagnostic accuracy of Doppler ultrasound, CT and MRI in Budd Chiari syndrome: systematic review and meta-analysis

Pankaj Gupta et al. Br J Radiol. .

Abstract

Objective: To evaluate the sensitivity, specificity, and diagnostic odds ratio (DOR) of Doppler ultrasound, CT, and MRI in the diagnosis of Budd Chiari syndrome (BCS).

Methods: We performed a literature search in PubMed, Embase, and Scopus to identify articles reporting the diagnostic accuracy of Doppler ultrasound, CT, and MRI (either alone or in combination) for BCS using catheter venography or surgery as the reference standard. The quality of the included articles was assessed by using the Quality Assessment of Diagnostic Accuracy Studies-2 tool.

Results: 11 studies were found eligible for inclusion. Pooled sensitivities and specificities of Doppler ultrasound were 89% [95% confidence interval (CI), 81-94%, I2 = 24.7%] and 68% (95% CI, 3-99%, I2 = 95.2%), respectively. Regarding CT, the pooled sensitivities and specificities were 89% (95% CI, 77-95%, I2 = 78.6%) and 72% (95% CI, 21-96%, I2 = 91.4%), respectively. The pooled sensitivities and specificities of MRI were 93% (95% CI, 89-96%, I2 = 10.6%) and 55% (95% CI, 5-96%, I2 = 87.6%), respectively. The pooled DOR for Doppler ultrasound, CT, and MRI were 10.19 (95% CI: 1.5, 69.2), 14.57 (95% CI: 1.13, 187.37), and 20.42 (95% CI: 1.78, 234.65), respectively. The higher DOR of MRI than that of Doppler ultrasound and CT shows the better discriminatory power. The area under the curve for MRI was 90.8% compared with 88.4% for CT and 86.6% for Doppler ultrasound.

Conclusion: Doppler ultrasound, CT and MRI had high overall diagnostic accuracy for diagnosis of BCS, but substantial heterogeneity was found. Prospective studies are needed to investigate diagnostic performance of these imaging modalities.

Advances in knowledge: MRI and CT have the highest meta-analytic sensitivity and specificity, respectively for the diagnosis of BCS. Also, MRI has the highest area under curve for the diagnosis of BCS.

PubMed Disclaimer

Figures

Figure 1.
Figure 1.
Flowchart of study inclusion.
Figure 2.
Figure 2.
Forest plots demonstrate the sensitivities and specificities of Doppler ultrasound, CT, and MRI.
Figure 3.
Figure 3.
Summary receiver operating characteristic curves for Doppler ultrasound, CT, and MRI.
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Janssen HLA, Garcia-Pagan J-C, Elias E, Mentha G, Hadengue A, Valla D-C, et al. . Budd-Chiari syndrome: a review by an expert panel. J Hepatol 2003; 38: 364–71. doi: 10.1016/S0168-8278(02)00434-8 - DOI - PubMed
    1. Bansal V, Gupta P, Sinha S, Dhaka N, Kalra N, Vijayvergiya R, et al. . Budd-Chiari syndrome: imaging review. Br J Radiol 2018; 91: 20180441. doi: 10.1259/bjr.20180441 - DOI - PMC - PubMed
    1. Grus T, Lambert L, Grusová G, Banerjee R, Burgetová A, Syndrome B-C. Budd-Chiari syndrome. Prague Med Rep 2017; 118(2-3): 69–80. doi: 10.14712/23362936.2017.6 - DOI - PubMed
    1. Goel RM, Johnston EL, Patel KV, Wong T. Budd-Chiari syndrome: investigation, treatment and outcomes. Postgrad Med J 2015; 91: 692–7. doi: 10.1136/postgradmedj-2015-133402 - DOI - PubMed
    1. Chaubal N, Dighe M, Hanchate V, Thakkar H, Deshmukh H, Rathod K. Sonography in Budd-Chiari syndrome. J Ultrasound Med 2006; 25: 373–9. doi: 10.7863/jum.2006.25.3.373 - DOI - PubMed

MeSH terms