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Review
. 2020 Jul 3;11(4):655-679.
doi: 10.1080/19490976.2020.1731287. Epub 2020 Mar 9.

The mycobiota of the human body: a spark can start a prairie fire

Di Zhang  1 , Ying Wang  1 , Sunan Shen  1   2 , Yayi Hou  1   2 , Yugen Chen  3 , Tingting Wang  1   2
Affiliations
Review

The mycobiota of the human body: a spark can start a prairie fire

Di Zhang et al. Gut Microbes. .

Abstract

Mycobiota are inseparable from human health, shaking up the unique position held by bacteria among microorganisms. What is surprising is that this seemingly small species can trigger huge changes in the human body. Dysbiosis and invasion of mycobiota are confirmed to cause disease in different parts of the body. Meanwhile, our body also produces corresponding immune changes upon mycobiota infection. Several recent studies have made a connection between intestinal mycobiota and the human immune system. In this review, we focus on questions related to mycobiota, starting with an introduction of select species, then we summarize the typical diseases caused by mycobiota in different parts of the human body. Moreover, we constructed a framework for the human anti-fungal immune system based on genetics and immunology. Finally, the progression of fungal detection methods is also reviewed.

Keywords: Mycobiota; colorectal carcinogenesis; detection methods; host-microbe interaction; immunity.

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Figures

Figure 1.
Figure 1.
Time line of clinical progress of mycobiota and related diseases in various parts of the human body.
Figure 2.
Figure 2.
The influence of mycobiota on IBD and colorectal carcinogenesis.
Figure 3.
Figure 3.
Gut-lung axis.
Figure 4.
Figure 4.
The reaction between mycobiota and immune system.
Figure 5.
Figure 5.
Fungal detected methods.
See this image and copyright information in PMC

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