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. 2020 Apr;7(4):554-558.
doi: 10.1002/acn3.50997. Epub 2020 Mar 9.

Vitamin D concentration and focal brain atrophy in older adults: a voxel-based morphometric study

Pauline Ali  1   2 , Matthieu Labriffe  1   3 , Nastassia Navasiolava  4 , Marc-Antoine Custaud  4   5 , Mickaël Dinomais  1   2 , Cédric Annweiler  6   7   8   9   10 ; SAM group
Affiliations

Vitamin D concentration and focal brain atrophy in older adults: a voxel-based morphometric study

Pauline Ali et al. Ann Clin Transl Neurol. 2020 Apr.

Abstract

Vitamin D is involved in brain health and function. Our objective was to determine whether lower 25-hydroxyvitamin D (25OHD) concentration was associated with focal brain volume reduction in older adults. Serum 25OHD concentration was measured among 53 older adults (72 ± 5 years; 38% female; mean 25OHD = 67.3 ± 20.8 nmol/L). Gray matter volume (GMV) was automatically segmented using voxel-based morphometry with CAT12 software. Covariables were age, gender, education, total intracranial volume, and season. Serum 25OHD was positively associated with GMV in left calcarine sulcus (P < 0.05, TFCE, FWE-corrected). We found atrophy of the calcarine sulcus with lower 25OHD concentrations in older adults.

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Conflict of interest statement

C. Annweiler serves as an editor for Maturitas. All authors declare they do not have any other financial and personal conflicts of interest with this manuscript.

Figures

Figure 1
Figure 1
Gray matter region showing a positive association with serum 25‐hydroxyvitamin D concentration (red color). GMV: gray matter volume. The statistical map was co‐registered and superimposed on 3D‐T1 (A) sagittal slice (MNI coordinates: X = 82), (B) coronal slice (MNI coordinates: Y = 81), and (C) axial slice (MNI coordinates: Z = 80) (MNI T1 template available on MRICRON software; TFCE from 10 to 1397). Results are showed with a significance of P < 0.05 corrected for multiple comparisons (TFCE, FWE‐corrected).
See this image and copyright information in PMC

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