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Review
. 2020 Mar 5;9(3):627.
doi: 10.3390/cells9030627.

Regulation of Necroptosis by Phospholipids and Sphingolipids

Xuewei Zhang  1 , Masaya Matsuda  2 , Nobuo Yaegashi  1 , Takeshi Nabe  2 , Kazuyuki Kitatani  2
Affiliations
Review

Regulation of Necroptosis by Phospholipids and Sphingolipids

Xuewei Zhang et al. Cells. .

Abstract

Several non-apoptotic regulated cell death pathways have been recently reported. Necroptosis, a form of necrotic-regulated cell death, is characterized by the involvement of receptor-interacting protein kinases and/or the pore-forming mixed lineage kinase domain-like protein. Recent evidence suggests a key role for lipidic molecules in the regulation of necroptosis. The purpose of this mini-review is to outline the regulation of necroptosis by sphingolipids and phospholipids.

Keywords: ceramide; fatty acids; lipids; mixed lineage kinase-domain like; necroptosis; phosphatidylinositols.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
MLKL structure and phospholipid-binding region. (A) Domains of human MLKL; (B) Amino acids (red) responsible for binding to phospholipids. MLKL, mixed lineage kinase domain-like protein.
Figure 2
Figure 2
Proposed model for necroptosis induced by ceramide.
See this image and copyright information in PMC

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