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. 2020 Mar;17(3):268-274.
doi: 10.30773/pi.2019.0254. Epub 2020 Mar 11.

Mental Disorders and Interferon Nontreatment in Hepatitis C Virus Infection-a Population Based Cohort Study

Wei-Che Chiu  1   2 , Mong-Liang Lu  3   4 , Cheng-Chen Chang  5   6   7
Affiliations

Mental Disorders and Interferon Nontreatment in Hepatitis C Virus Infection-a Population Based Cohort Study

Wei-Che Chiu et al. Psychiatry Investig. 2020 Mar.

Abstract

Objective: This study investigates the association between mental disorders and interferon nontreatment in patients with chronic hepatitis C virus (HCV) infection in a large national sample.

Methods: Using the National Health Insurance Research Database of Taiwan, we conducted a nationwide population-based study. Each case was matched to five controls by age, sex, urbanization, and income. Conditional logistic regression was used to assess odds of HCV nontreatment in different mental disorders.

Results: From 1999 to 2013, we identified 92,970 subjects with HCV infection and 15,495 HCV cases (16.7%) had received IFN therapy. Other than chronic obstructive pulmonary disease, the medical diseases and mental disorders were significantly different between IFN and non-IFN treated HCV patients. After adjusting for medical diseases, depressive disorder and anxiety disorder was positively associated with receiving IFN therapy. Patients with schizophrenia, bipolar disorders and alcohol use disorders were significantly less likely to receive interferon. Antidepressant exposure (cumulative daily exposure or cumulative daily dose) was associated with lower odds of IFN treatment.

Conclusion: Our nationwide cohort study demonstrated that INF nontreatment rate was lower in certain mental disorders. Antidepressant exposure might lower the chance of receiving IFN treatment. Our results may help to identify and to overcome the obstacles for HCV treatment and further apply to DAAs regimen.

Keywords: Anxiety; Depression; Hepatitis C; Interferon non-treatment; Mental disorders.

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Conflict of interest statement

The authors have no potential conflicts of interest to disclose.

Figures

Figure 1.
Figure 1.
Flow chart of the study subject enrollment. HCV: hepatitis C virus, IFN: interferon.
See this image and copyright information in PMC

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References

    1. Poynard T, Yuen MF, Ratziu V, Lai CL. Viral hepatitis C. Lancet. 2003;362:2095–2100. - PubMed
    1. Shiffman ML, Morishima C, Dienstag JL, Lindsay KL, Hoefs JC, Lee WM, et al. Effect of HCV RNA suppression during peginterferon alfa2a maintenance therapy on clinical outcomes in the HALT-C trial. Gastroenterology. 2009;137:1986–1994. - PMC - PubMed
    1. NIH Consensus Statement on Management of Hepatitis C 2002. NIH Consens State Sci Statements. 2002;19:1–46. - PubMed
    1. Okanoue T, Minami M, Makiyama A, Sumida Y, Yasui K, Itoh Y. Natural course of asymptomatic hepatitis C virus-infected patients and hepatocellular carcinoma after interferon therapy. Clin Gastroenterol Hepatol. 2005;3:S89–S91. - PubMed
    1. Chu CJ, Lee SD. Hepatitis B virus/hepatitis C virus coinfection: epidemiology, clinical features, viral interactions and treatment. J Gastroenterol Hepatol. 2008;23:512–520. - PubMed

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