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Review
. 2020 Apr;29(2):223-241.
doi: 10.1016/j.soc.2019.11.006.

Management of Small Bowel Neuroendocrine Tumors

Aaron T Scott  1 , James R Howe  2
Affiliations
Review

Management of Small Bowel Neuroendocrine Tumors

Aaron T Scott et al. Surg Oncol Clin N Am. 2020 Apr.

Abstract

Small bowel neuroendocrine tumors (SBNETS) are slow-growing neoplasms with a noted propensity toward metastasis and comparatively favorable prognosis. The presentation of SBNETs is varied, although abdominal pain and obstructive symptoms are the most common presenting symptoms. In patients with metastases, hypersecretion of serotonin and other bioactive amines results in diarrhea, flushing, valvular heart disease, and bronchospasm, termed carcinoid syndrome. The treatment of SBNETs is multimodal and includes surgery, liver-directed therapy, somatostatin analogues, targeted therapy, and peptide receptor radionuclide therapy.

Keywords: Carcinoid; Neuroendocrine tumor; SBNET; Small bowel; Surgery.

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Conflict of interest statement

Disclosure The authors have no conflicts of interest to disclose. This work was supported by the T32 grant CA148062-0 (A.T. Scott) and SPORE grant P50 CA174521-01 (J.R. Howe).

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