KISS1 in metastatic cancer research and treatment: potential and paradoxes

doi:10.1007/s10555-020-09868-9

Review

. 2020 Sep;39(3):739-754.

doi: 10.1007/s10555-020-09868-9.

KISS1 in metastatic cancer research and treatment: potential and paradoxes

Thuc Ly¹, Sitaram Harihar², Danny R Welch^{3

4}

Affiliations

¹ Department of Cancer Biology, Kansas University Medical Center, 3901 Rainbow Blvd. - MS1071, Kansas City, KS, 66160, USA.
² Department of Genetic Engineering, SRM Institute of Science and Technology, Kattankulathur, Chennai, Tamil Nadu, 603203, India.
³ Department of Cancer Biology, Kansas University Medical Center, 3901 Rainbow Blvd. - MS1071, Kansas City, KS, 66160, USA. DWelch@KUMC.edu.
⁴ University of Kansas Cancer Center, 3901 Rainbow Blvd., Kansas City, KS, 66160, USA. DWelch@KUMC.edu.

PMID: 32152912
PMCID: PMC7483209
DOI: 10.1007/s10555-020-09868-9

Review

KISS1 in metastatic cancer research and treatment: potential and paradoxes

Thuc Ly et al. Cancer Metastasis Rev. 2020 Sep.

. 2020 Sep;39(3):739-754.

doi: 10.1007/s10555-020-09868-9.

Authors

Thuc Ly¹, Sitaram Harihar², Danny R Welch^{3

4}

Affiliations

¹ Department of Cancer Biology, Kansas University Medical Center, 3901 Rainbow Blvd. - MS1071, Kansas City, KS, 66160, USA.
² Department of Genetic Engineering, SRM Institute of Science and Technology, Kattankulathur, Chennai, Tamil Nadu, 603203, India.
³ Department of Cancer Biology, Kansas University Medical Center, 3901 Rainbow Blvd. - MS1071, Kansas City, KS, 66160, USA. DWelch@KUMC.edu.
⁴ University of Kansas Cancer Center, 3901 Rainbow Blvd., Kansas City, KS, 66160, USA. DWelch@KUMC.edu.

PMID: 32152912
PMCID: PMC7483209
DOI: 10.1007/s10555-020-09868-9

Abstract

The significance of KISS1 goes beyond its original discovery as a metastasis suppressor. Its function as a neuropeptide involved in diverse physiologic processes is more well studied. Enthusiasm regarding KISS1 has cumulated in clinical trials in multiple fields related to reproduction and metabolism. But its cancer therapeutic space is unsettled. This review focuses on collating data from cancer and non-cancer fields in order to understand shared and disparate signaling that might inform clinical development in the cancer therapeutic and biomarker space. Research has focused on amino acid residues 68-121 (kisspeptin 54), binding to the KISS1 receptor and cellular responses. Evidence and counterevidence regarding this canonical pathway require closer look at the covariates so that the incredible potential of KISS1 can be realized.

Keywords: Dormancy; G protein-coupled receptor; KISS1; KISS1R; Metastasis; Metastasis suppressor.

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Conflict of interest statement

Conflicts of interest: The authors declare no conflicts of interest.

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References

1. Lee J-H, Doumen DJ, & Welch DR (1996). Cloning of a novel gene, KiSS-1, which is responsible for metastasis suppression in chromosome 6/human melanoma hybrid cells. PNAS, 37, 531.
1. Ohtaki T, Shintani Y, Honda S, Matsumoto H, Hori A, Kanehashi K, et al. (2001). Metastasis suppressor gene KiSS1 encodes peptide ligand of a G-protein-coupled receptor. Nature, 411(6837), 613–617. - PubMed
1. Kotani M, Detheux M, Vandenbogaerde A, Communi D, Vanderwinden JM, Le Poul E, et al. (2001). The metastasis suppressor gene KiSS-1 encodes kisspeptins, the natural ligands of the orphan G protein-coupled receptor GPR54. J Biol Chem, 276(37), 34631–34636. - PubMed
1. Muir AI, Chamberlain L, Elshourbagy NA, Michalovich D, Moore DJ, Calamari A, et al. (2001). AXOR12, a novel human G protein-coupled receptor, activated by the peptide KiSS-1. J Biol Chem, 276(31), 28969–28975. - PubMed
1. Uenoyama Y, Inoue N, Maeda KI, & Tsukamura H (2018). The roles of kisspeptin in the mechanism underlying reproductive functions in mammals. J Reprod Dev, 64(6), 469–476. - PMC - PubMed

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[1] Lee J-H, Doumen DJ, & Welch DR (1996). Cloning of a novel gene, KiSS-1, which is responsible for metastasis suppression in chromosome 6/human melanoma hybrid cells. PNAS, 37, 531.

[2] Lee J-H, Doumen DJ, & Welch DR (1996). Cloning of a novel gene, KiSS-1, which is responsible for metastasis suppression in chromosome 6/human melanoma hybrid cells. PNAS, 37, 531.

[3] Ohtaki T, Shintani Y, Honda S, Matsumoto H, Hori A, Kanehashi K, et al. (2001). Metastasis suppressor gene KiSS1 encodes peptide ligand of a G-protein-coupled receptor. Nature, 411(6837), 613–617. - PubMed

[4] Ohtaki T, Shintani Y, Honda S, Matsumoto H, Hori A, Kanehashi K, et al. (2001). Metastasis suppressor gene KiSS1 encodes peptide ligand of a G-protein-coupled receptor. Nature, 411(6837), 613–617. - PubMed

[5] Kotani M, Detheux M, Vandenbogaerde A, Communi D, Vanderwinden JM, Le Poul E, et al. (2001). The metastasis suppressor gene KiSS-1 encodes kisspeptins, the natural ligands of the orphan G protein-coupled receptor GPR54. J Biol Chem, 276(37), 34631–34636. - PubMed

[6] Kotani M, Detheux M, Vandenbogaerde A, Communi D, Vanderwinden JM, Le Poul E, et al. (2001). The metastasis suppressor gene KiSS-1 encodes kisspeptins, the natural ligands of the orphan G protein-coupled receptor GPR54. J Biol Chem, 276(37), 34631–34636. - PubMed

[7] Muir AI, Chamberlain L, Elshourbagy NA, Michalovich D, Moore DJ, Calamari A, et al. (2001). AXOR12, a novel human G protein-coupled receptor, activated by the peptide KiSS-1. J Biol Chem, 276(31), 28969–28975. - PubMed

[8] Muir AI, Chamberlain L, Elshourbagy NA, Michalovich D, Moore DJ, Calamari A, et al. (2001). AXOR12, a novel human G protein-coupled receptor, activated by the peptide KiSS-1. J Biol Chem, 276(31), 28969–28975. - PubMed

[9] Uenoyama Y, Inoue N, Maeda KI, & Tsukamura H (2018). The roles of kisspeptin in the mechanism underlying reproductive functions in mammals. J Reprod Dev, 64(6), 469–476. - PMC - PubMed

[10] Uenoyama Y, Inoue N, Maeda KI, & Tsukamura H (2018). The roles of kisspeptin in the mechanism underlying reproductive functions in mammals. J Reprod Dev, 64(6), 469–476. - PMC - PubMed

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KISS1 in metastatic cancer research and treatment: potential and paradoxes

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KISS1 in metastatic cancer research and treatment: potential and paradoxes

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