Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2019 Dec 6:34:182.
doi: 10.11604/pamj.2019.34.182.16275. eCollection 2019.

Prevalence and factors associated with hepatitis B in a cohort of HIV-infected children in the Pediatric Department at Donka National Hospital, Guinea

Djiba Kaba  1   2 , Mmah Aminata Bangoura  1   3 , Mariame Moustapha Sylla  3 , Fodé Bangaly Sako  1   4 , Mariama Sadjo Diallo  1   2 , Issiaga Diallo  1   2 , Ouo-Ouo Yaramon Kolié  2 , Ahmed Sékou Keita  5 , Boh Fanta Diané  1   5 , Fatimata Keita  1   5 , Mamady Diakité  1 , Mamadou Diouldé Kanté  1   5 , Moussa Savané  1   5 , Djibril Sylla  1   6 , Amadou Kaké  1   7 , Kadiatou Diallo  1   8 , Mafoudia Touré  3 , Mohamed Cissé  1   5
Affiliations

Prevalence and factors associated with hepatitis B in a cohort of HIV-infected children in the Pediatric Department at Donka National Hospital, Guinea

Djiba Kaba et al. Pan Afr Med J. .

Abstract

Introduction: children pay a heavy price for infection with the hepatitis B virus (HBV). The objective of this work was to determine the prevalence of hepatitis B and describe the associated factors in children at the pediatric department of Donka Hospital.

Methods: this was a cross-sectional study of a cohort of children in the pediatric department of Donka Hospital. HBsAg was performed by using an immunochromatographic method. The analysis of the data was done with software R. The proportions were compared using the Chi-square test or the Fisher test at the significance level of 5%. A logistic regression model was used to explain the prevalence of hepatitis B.

Results: one hundred and forty-nine children were recruited between February and July 2017. HBsAg was present in 12 children, i.e. 8.16% (95% CI: 4.29-13.82). The average age was 93.32 months (IQR: 6-180). Male children were the most affected (n = 11, P <0.05), with a sex ratio of 1.01. The majority (51.35%) were on AZT + 3TC + NVP pediatric form and 25% were on AZT + 3TC + NVP adult form and 23.65% on TDF + FTC + EFV. In univariate analysis, ALT, HBsAg positivity, and maternal HBV vaccination status were associated with the prevalence of HBsAg (P <0.05).

Conclusion: the prevalence of co-infection in children and adults is almost identical in our context. Hence the importance of strengthening preventive measures at all levels, especially the vaccination of children and mothers.

Keywords: Donka National Hospital; Guinea; HIV; Hepatitis B; paediatrics; prevalence.

PubMed Disclaimer

Conflict of interest statement

The authors declare no competing interests.

References

    1. OMS . Hépatite B. Accessed 12 March 2018.
    1. OMS . RAPPORT MONDIAL SUR L'HÉPATITE, 2017. Accessed 12 March 2018.
    1. Réseau africain pour les soins aux enfants affectés par le sida (ANECCA) Manuel sur le sida pédiatrique en Afrique. Accessed 12 March 2018.
    1. OMS . Les nouvelles données sur l'hépatite soulignent le besoin urgent d'une riposte mondiale. Accessed 12 March 2018.
    1. Toussi SS, Abadi J, Rosenberg M, Levanon D. Prevalence of hepatitis B and C virus infections in children infected with HIV. Clin Infect Dis Off Publ Infect Dis Soc Am. 2007;45(6):795–798. - PubMed

MeSH terms