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. 2018 Feb 2:4:1.
doi: 10.1186/s40795-017-0207-6. eCollection 2018.

Impact of vitamin D supplementation on C-reactive protein; a systematic review and meta-analysis of randomized controlled trials

Mohsen Mazidi  1   2 , Peyman Rezaie  3 , Hassan Vatanparast  4
Affiliations

Impact of vitamin D supplementation on C-reactive protein; a systematic review and meta-analysis of randomized controlled trials

Mohsen Mazidi et al. BMC Nutr. .

Abstract

Background: To evaluate the effect of vitamin D supplementation on C-reactive protein (CRP) through a systematic review and meta-analysis of randomized control trials (RCTs).

Methods: PubMed-Medline, SCOPUS, Google Scholar and Web of Science databases were searched (up until April 2016) to identify RCTs evaluating the impact of vitamin D supplementation on CRP. We used random effects models (using DerSimonian-Laird method) as well as the generic inverse variance methods for quantitative data synthesis. For sensitivity analysis, we applied leave-one-out approach. To examine the heterogeneity we used I2 index. Registration code: CRD42016036932.

Results: Among 1274 search items, 24 studies met the inclusion criteria in the final evaluation. Pooling the data together indicated a non-significant decrease in CRP level following administration of vitamin D (weighted mean difference [WMD] -0.26(mg/l), (95% CI -0.75 to 0.22, N = 26 arms, heterogeneity p = 0.042; I2 54.2%). The WMDs for IL6 was 0.67 pg/ml, (95% CI 0.29 to 1.06, N = 16 arms, heterogeneity p = 0.234; I2 19.1%), 0.43 pg/ml, (95% CI 0.08 to 1.05, N = 26 arms, heterogeneity p = 0.120; I2 42.1%), for IL10, and -0.11 pg/ml, (95% CI -0.53 to 0.30, N = 12 arms, heterogeneity p = 0.423; I2 9.2%) for TNF-α, 4.03 pg/ml, (95% CI 3.50 to 4.57, N = 3 arms, heterogeneity p = 0.752; I2 8.1%) for adiponectin. Sensitivity analyses confirmed the robustness of the findings.

Conclusions: This study provided evidence that vitamin D supplementation had no impact on serum CRP, IL10, and TNF-α, while significantly increased serum IL6. We recommend RCTs with longer period of follow-up time (12 months) for future studies to provide explicit results.

Keywords: C-reactive protein; Meta-analysis; Vitamin D supplementation.

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Conflict of interest statement

Competing interestsThe authors declare that they have no competing interests.

Figures

Fig. 1
Fig. 1
PRISMA flow chart for the studies selection
Fig. 2
Fig. 2
Weighted mean difference of the effect of vitamin D supplementation on C-reactive protein
Fig. 3
Fig. 3
Weighted mean difference of the effect of vitamin D supplementation on IL-6
Fig. 4
Fig. 4
Funnel plot of standard error by Std difference in means
Fig. 5
Fig. 5
Funnel plot of standard error by Std difference in means
See this image and copyright information in PMC

References

    1. Holick MF, Vitamin D. deficiency. N Engl J Med. 2007;357(3):266–281. doi: 10.1056/NEJMra070553. - DOI - PubMed
    1. Canning MO, Grotenhuis K, de Wit H, Ruwhof C, Drexhage HA. 1-alpha, 25-Dihydroxyvitamin D3 (1, 25 (OH)(2) D (3)) hampers the maturation of fully active immature dendritic cells from monocytes. Eur J Endocrinol. 2001;145(3):351–357. doi: 10.1530/eje.0.1450351. - DOI - PubMed
    1. McCarty MF. Secondary hyperparathyroidism promotes the acute phase response–a rationale for supplemental vitamin D in prevention of vascular events in the elderly. Med Hypotheses. 2005;64(5):1022–1026. doi: 10.1016/j.mehy.2004.03.041. - DOI - PubMed
    1. Zhu Y, Mahon BD, Froicu M, Cantorna MT. Calcium and 1α, 25-dihydroxyvitamin D3 target the TNF-α pathway to suppress experimental inflammatory bowel disease. Eur J Immunol. 2005;35(1):217–224. doi: 10.1002/eji.200425491. - DOI - PubMed
    1. Gepner AD, Ramamurthy R, Krueger DC, Korcarz CE, Binkley N, Stein JHA. Prospective randomized controlled trial of the effects of vitamin D supplementation on cardiovascular disease risk. PLoS One. 2012;7(5):e36617. doi: 10.1371/journal.pone.0036617. - DOI - PMC - PubMed

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